Promethazine and Accutane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Accutane (isotretinoin). Common drug interactions include crohn's disease among females and gastrooesophageal reflux disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Accutane. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Accutane?

Accutane has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 35,221 Accutane users. Check the latest studies of Accutane.

On Apr, 27, 2026

14 people who take Promethazine and Accutane together, and have interactions are studied.

Promethazine and Accutane drug interactions.

What are the common drug interactions of Promethazine and Accutane, by gender? *:

female:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Inflammatory bowel disease
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Cholangitis sclerosing (infection and obstruction of bile duct)
Depression
Eczema asteatotic (severe dry skin- during the winter months and in the elderly)
Irritable bowel syndrome

male:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Injury
Epistaxis (bleed from the nose)
General physical health deterioration (weak health status)
Intestinal haemorrhage (bleeding from intestine)
Irritable bowel syndrome
Lip dry
Mood swings (an extreme or rapid change in mood)
Pain
Rash

What are the common drug interactions of Promethazine and Accutane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Back pain
Dislocation of vertebra
Fall
Foot fracture
Road traffic accident
Abdominal pain
Anxiety
Colitis ulcerative (inflammation of colon with ulcer)
Cyst (a closed sac)
Inflammatory bowel disease

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)

30-39:

Anxiety
Cerebral venous thrombosis (clot in brains venous blood system)
Colitis ulcerative (inflammation of colon with ulcer)
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dry skin
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Emotional distress
Epistaxis (bleed from the nose)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

40-49:

Tooth extraction
White blood cell count increased
Chronic kidney disease
Acute tonsillitis
Anal fistula
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Emotional distress
Epistaxis (bleed from the nose)
Headache (pain in head)
Inflammatory bowel disease

50-59:

Breast cancer metastatic
Drug hypersensitivity
Nasopharyngitis (inflammation of the nasopharynx)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 28.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 21.43%
Pain: 2 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%
Depression: 2 people, 14.29%
Stress And Anxiety: 1 person, 7.14%
Heart Rate Increased: 1 person, 7.14%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 7.14%
Birth Control: 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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