Promethazine and Imiquimod drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Imiquimod (imiquimod). Common drug interactions include surgery among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Imiquimod. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Imiquimod?

Imiquimod has active ingredients of imiquimod. eHealthMe is studying from 2,038 Imiquimod users. Check the latest studies of Imiquimod.



On Jul, 09, 2026

33 people who take Promethazine and Imiquimod together, and have interactions are studied.

Promethazine and Imiquimod drug interactions.

What are the common drug interactions of Promethazine and Imiquimod, by gender? *:

female:

  1. Surgery
  2. Abscess limb (limb infection)
  3. Anal abscess
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  5. Anxiety
  6. Chronic kidney disease
  7. Cystitis (inflammation of the wall of the bladder)
  8. Decreased activity
  9. Depression
  10. Emotional distress

male:

  1. Chronic kidney disease
  2. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  3. Bone density decreased
  4. Bone metabolism disorder
  5. Multiple fractures
  6. Tooth loss
  7. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  8. Hip arthroplasty
  9. Rotator cuff repair
  10. Spinal cord injury

What are the common drug interactions of Promethazine and Imiquimod, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Pain
  5. Chronic kidney disease
  6. Bone density decreased
  7. Bone loss
  8. Hand fracture
  9. Osteopenia (a condition where bone mineral density is lower than normal)
  10. Osteoporosis (bones weak and more likely to break)

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Emotional distress
  4. Pain
  5. Chronic kidney disease
  6. Osteopenia (a condition where bone mineral density is lower than normal)
  7. Renal failure (kidney dysfunction)
  8. Bone density decreased
  9. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  10. Hip arthroplasty

50-59:

  1. Renal failure (kidney dysfunction)
  2. Bone metabolism disorder
  3. Renal impairment (severely reduced kidney function)
  4. Asthenia (weakness)
  5. Depression
  6. Hip fracture
  7. Osteopenia (a condition where bone mineral density is lower than normal)
  8. Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
  9. Tooth injury
  10. Tooth loss

60+:

  1. Chronic kidney disease
  2. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  3. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  4. Intestinal obstruction

What are the existing conditions these people have? *

  1. Hiv Infection: 27 people, 81.82%
  2. High Blood Cholesterol: 4 people, 12.12%
  3. Diabetes: 3 people, 9.09%
  4. High Blood Pressure: 3 people, 9.09%
  5. Herpes Virus Infection: 2 people, 6.06%
  6. Bone Pain: 2 people, 6.06%
  7. Deformity (disfigurement): 2 people, 6.06%
  8. Depression: 2 people, 6.06%
  9. Erection Problems: 2 people, 6.06%
  10. Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Promethazine and Imiquimod:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Promethazine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Imiquimod:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Promethazine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Imiquimod and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on promethazine hydrochloride and imiquimod (the active ingredients of Promethazine and Imiquimod, respectively), and Promethazine and Imiquimod (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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