Promethazine and Mesalamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Mesalamine (mesalamine). Common drug interactions include rash pruritic among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Mesalamine. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

83 people who take Promethazine and Mesalamine together, and have interactions are studied.

Promethazine and Mesalamine drug interactions.

What are the common drug interactions of Promethazine and Mesalamine, by gender? *:

female:

Rash pruritic (redness with itching)
Restlessness (not able to rest)
Speech disorder
Spinal fracture (fracture in one of vertebrae)
Streptococcus test positive
Abdominal pain upper
Abdominal wall mass
Age-related macular degeneration
Anal haemorrhage
Aortic valve incompetence

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Renal failure acute (rapid kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Acute stress disorder
Anaphylactic reaction (serious allergic reaction)
Aphonia (inability to produce voice)
Arthropathy
Bone density decreased
Bone loss

What are the common drug interactions of Promethazine and Mesalamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anaphylactic reaction (serious allergic reaction)

20-29:

n/a

30-39:

Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Anaemia (lack of blood)
Septic shock (shock due to blood infection)
Clostridium difficile sepsis (infection(pus formation) of colon by clostridium difficile bacteria)
Dehydration (dryness resulting from the removal of water)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Pneumonia
Pyrexia (fever)

40-49:

Aphonia (inability to produce voice)
Arthralgia (joint pain)
Cellulitis (infection under the skin)
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Cholecystitis acute (rapid infection of gallbladder)
Constipation
Device related infection
Diarrhoea
Dry mouth
Gastrointestinal inflammation (inflammation of stomach and intestine)

50-59:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Sepsis (a severe blood infection that can lead to organ failure and death)
Intestinal obstruction
Age-related macular degeneration
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Epistaxis (bleed from the nose)
Nasopharyngitis (inflammation of the nasopharynx)
Rash

60+:

Pain
Malaise (a feeling of general discomfort or uneasiness)
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Rectal haemorrhage (bleeding from anus)
Abdominal pain
Frequent bowel movements
Constipation
Erythema (redness of the skin)
Female genital tract fistula (passage in genital tract of female)

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 26 people, 31.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 14.46%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 11 people, 13.25%
Migraine (headache): 9 people, 10.84%
Cystitis Interstitial (unknown cause characterized by bladder pain): 9 people, 10.84%
Depression: 9 people, 10.84%
Pain: 9 people, 10.84%
Stress And Anxiety: 8 people, 9.64%
Allergies: 8 people, 9.64%
Indigestion: 7 people, 8.43%

* Approximation only. Some reports may have incomplete information.

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