Promethazine and Retin-a drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Retin-a (tretinoin). Common drug interactions include abdominal discomfort among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Retin-a. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Retin-a?

Retin-a has active ingredients of tretinoin. It is often used in acne. eHealthMe is studying from 2,475 Retin-a users. Check the latest studies of Retin-a.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

22 people who take Promethazine and Retin-a together, and have interactions are studied.

Promethazine and Retin-a drug interactions.

What are the common drug interactions of Promethazine and Retin-A, by gender? *:

female:

Abdominal discomfort
Abdominal pain
Anaphylactic reaction (serious allergic reaction)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Appetite disorder (abnormal eating habits)
Arthralgia (joint pain)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Asthenia (weakness)
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Emotional distress
Pain
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Promethazine and Retin-A, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Heart rate increased
Injury
Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
Pain
Panic attack
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

30-39:

n/a

40-49:

Chronic kidney disease
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
Renal failure (kidney dysfunction)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Chronic kidney disease
Emotional distress
Pain
Renal impairment (severely reduced kidney function)

60+:

Abdominal discomfort
Abdominal pain
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dizziness
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Dry skin
Dysphagia (a condition in which swallowing is difficult or painful)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 54.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 45.45%
Drowsiness: 4 people, 18.18%
Dizziness: 3 people, 13.64%
Pain: 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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