Spironolactone and Renal injury - a phase IV clinical study of FDA data

Summary:

Renal injury is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Renal injury when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Renal injury?

Renal injury (kidney injury) is found to be associated with 1,203 drugs and 795 conditions by eHealthMe. Check the latest studies of Renal injury.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 746 people (0.63%) have Renal injury.

Could Spironolactone cause Renal injury?

Among these 746 people:

How long have people been on Spironolactone when they have Renal injury? *

Click here to view more results

What is the gender of people who have Renal injury when taking Spironolactone? *

Click here to view

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Renal injury?

- Check whether Renal injury is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Renal injury treatments and more:

Renal injury (61,065 reports)

How severe was Renal injury and when was it recovered:

Renal injury in Spironolactone

Expand to all the drugs that have ingredients of spironolactone:

Renal injury and drugs with ingredients of spironolactone (835 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Renal injury:

Renal injury (1,203 drugs)

Browse all the conditions that are associated with Renal injury:

Renal injury (795 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.