Promethazine and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethazine (promethazine hydrochloride) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include cellulitis among females.

The phase IV clinical study analyzes what interactions people have when they take Promethazine and Ziac. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

13 people who take Promethazine and Ziac together, and have interactions are studied.

Promethazine and Ziac drug interactions.

What are the common drug interactions of Promethazine and Ziac, by gender? *:

female:

Cellulitis (infection under the skin)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Dehydration (dryness resulting from the removal of water)
Chronic kidney disease
Device failure
Fungal infection
Abdominal discomfort
Infusion related reaction
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)

male:

n/a

What are the common drug interactions of Promethazine and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cellulitis (infection under the skin)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Staphylococcal abscess (pus formation due to staphylococcal bacteria)

40-49:

n/a

50-59:

n/a

60+:

Chronic kidney disease
Device failure
Abdominal discomfort
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 5 people, 38.46%
Pain: 4 people, 30.77%
Vulvovaginal Candidiasis (vulvovaginal infection by fungi): 3 people, 23.08%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 23.08%
Stress And Anxiety: 3 people, 23.08%
Constipation: 3 people, 23.08%
Pain In Extremity: 3 people, 23.08%
Oesophagitis (inflammation of oesophagus): 3 people, 23.08%
Depression: 3 people, 23.08%
Muscle Spasms (muscle contraction): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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