Promethegan and Gabapentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Promethegan (promethazine hydrochloride) and Gabapentin (gabapentin). Common drug interactions include hepatic enzyme increased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Promethegan and Gabapentin. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Promethegan?

Promethegan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 428 Promethegan users. Check the latest studies of Promethegan.

What is Gabapentin?

Gabapentin has active ingredients of gabapentin. It is often used in peripheral neuropathy. eHealthMe is studying from 322,987 Gabapentin users. Check the latest studies of Gabapentin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

98 people who take Promethegan and Gabapentin together, and have interactions are studied.

Promethegan and Gabapentin drug interactions.

What are the common drug interactions of Promethegan and Gabapentin, by gender? *:

female:

Hepatic enzyme increased
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypokinesia (decreased bodily movement)
Limb injury
Liver injury
Lower limb fracture
Lung disorder (lung disease)
Muscular weakness (muscle weakness)
Neck pain
Onychomycosis (fungal infection of the nail)

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pneumonia
Respiratory syncytial virus infection (viral disease of respiratory system)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arteriovenous fistula site complication
Gait disturbance
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Injury
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Promethegan and Gabapentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Intestinal obstruction
Volvulus (obstruction caused by twisting of the stomach or intestine)

30-39:

Cardiac arrest
Dyspnoea (difficult or laboured respiration)
Folliculitis (infection of hair root)
Gastrointestinal infection (infection of stomach and intestine)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Lung disorder (lung disease)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)

40-49:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Bone density decreased
Osteonecrosis (death of bone)
Rib fracture
Hypertension (high blood pressure)
Renal failure (kidney dysfunction)
Angina pectoris (chest pain due to ischemia of the heart muscle)

50-59:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hypersensitivity
Hypokinesia (decreased bodily movement)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Orbital oedema (swelling of orbit)
Osteoporosis (bones weak and more likely to break)
Pneumomediastinum (air is present in the mediastinum)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Renal tubular necrosis (death of kidney tubules)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Dizziness
Emotional distress

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 36 people, 36.73%
Hiv Infection: 29 people, 29.59%
High Blood Pressure: 28 people, 28.57%
Depression: 22 people, 22.45%
Stress And Anxiety: 18 people, 18.37%
Pain: 17 people, 17.35%
High Blood Cholesterol: 16 people, 16.33%
Infection: 15 people, 15.31%
Insomnia (sleeplessness): 14 people, 14.29%
Hypersensitivity: 13 people, 13.27%

* Approximation only. Some reports may have incomplete information.

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