Prometrium and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prometrium (progesterone) and Protonix (pantoprazole sodium). Common drug interactions include dysphonia among females and application site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Prometrium and Protonix. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

92 people who take Prometrium and Protonix together, and have interactions are studied.

Prometrium and Protonix drug interactions.

What are the common drug interactions of Prometrium and Protonix, by gender? *:

female:

Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pain
Epistaxis (bleed from the nose)
Fat tissue increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Generalised oedema (swelling all over the body)
Haematochezia (passage of stools containing blood)
Hypoacusis (loss of hearing)
Hypoaesthesia (reduced sense of touch or sensation)

male:

Application site pain
Application site pruritus (application site severe itching of the skin)
Epistaxis (bleed from the nose)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)
Application site scar

What are the common drug interactions of Prometrium and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Balance disorder
Breast mass
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Incision site haemorrhage (bleeding from incision site)
Injury
Nausea (feeling of having an urge to vomit)

30-39:

Abdominal pain upper
Arthralgia (joint pain)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Dyspepsia (indigestion)
Epicondylitis (tennis elbow)
Gallbladder disorder
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)

40-49:

Oedema peripheral (superficial swelling)
Dyspnoea (difficult or laboured respiration)
Weight increased
Breast mass
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug ineffective
Gait disturbance
Nausea (feeling of having an urge to vomit)
Pain in extremity

50-59:

Dehydration (dryness resulting from the removal of water)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Gait disturbance
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Lymphadenopathy (disease or enlargement of lymph nodes)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nail disorder (disease of nail)
Nausea (feeling of having an urge to vomit)

60+:

Fatigue (feeling of tiredness)
Fall
Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Depression
Diarrhoea
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Epistaxis (bleed from the nose)

What are the existing conditions these people have? *

Pain: 19 people, 20.65%
Depression: 15 people, 16.30%
Fibromyalgia (a long-term condition which causes pain all over the body): 15 people, 16.30%
High Blood Pressure: 14 people, 15.22%
Restless Leg Syndrome (a powerful urge to move your legs): 12 people, 13.04%
Urinary Tract Infection: 11 people, 11.96%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 11.96%
Hypertriglyceridaemia (excess of triglycerides in the blood): 11 people, 11.96%
Allergic Rhinitis: 11 people, 11.96%
Sinusitis (inflammation of sinus): 11 people, 11.96%

* Approximation only. Some reports may have incomplete information.

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