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Protonix and Augmentin xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Augmentin xr (amoxicillin; clavulanate potassium). Common drug interactions include dementia among females and abnormal behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Augmentin xr. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Augmentin xr?

Augmentin xr has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 522 Augmentin xr users. Check the latest studies of Augmentin xr.

On Jul, 28, 2026

15 people who take Protonix and Augmentin xr together, and have interactions are studied.

Protonix and Augmentin xr drug interactions.

What are the common drug interactions of Protonix and Augmentin Xr, by gender? *:

female:

  1. Dementia (madness)
  2. Renal cyst (kidney cyst)
  3. Renal disorder (kidney disease)
  4. Sepsis (a severe blood infection that can lead to organ failure and death)
  5. Suicidal ideation
  6. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Nephropathy (damage to or disease of a kidney)
  9. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  10. Type 2 diabetes mellitus

male:

  1. Abnormal behaviour
  2. Diabetes mellitus inadequate control
  3. Immune system disorder
  4. Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
  5. Pneumonia
  6. Type 2 diabetes mellitus

What are the common drug interactions of Protonix and Augmentin Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Abnormal behaviour
  2. Diabetes mellitus inadequate control
  3. Immune system disorder
  4. Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
  5. Type 2 diabetes mellitus

20-29:

n/a

30-39:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

40-49:

  1. Chronic kidney disease
  2. Nephrogenic anaemia (anaemia due to kidney disease)
  3. Renal failure (kidney dysfunction)

50-59:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
  4. Cystitis interstitial (unknown cause characterized by bladder pain)
  5. Dementia (madness)
  6. Renal cyst (kidney cyst)
  7. Renal disorder (kidney disease)
  8. Sepsis (a severe blood infection that can lead to organ failure and death)
  9. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  10. Nephropathy (damage to or disease of a kidney)

60+:

  1. Activities of daily living impaired
  2. Alcohol use
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Cubital tunnel syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow)
  5. Depression
  6. Diarrhoea
  7. Disturbance in attention
  8. Dizziness
  9. Drug abuse
  10. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)

What are the existing conditions these people have? *

  1. High Blood Pressure: 9 people, 60.00%
  2. Depression: 6 people, 40.00%
  3. Stress And Anxiety: 6 people, 40.00%
  4. Asthma: 6 people, 40.00%
  5. Diabetes: 6 people, 40.00%
  6. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 33.33%
  7. Dizziness: 4 people, 26.67%
  8. Migraine (headache): 4 people, 26.67%
  9. Nausea (feeling of having an urge to vomit): 4 people, 26.67%
  10. Osteomyelitis (infection of bone): 4 people, 26.67%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and Augmentin xr?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Protonix and Augmentin xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Augmentin xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Protonix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Augmentin xr and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium and amoxicillin; clavulanate potassium (the active ingredients of Protonix and Augmentin xr, respectively), and Protonix and Augmentin xr (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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