Protonix and Trulance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Trulance (plecanatide). Common drug interactions include chronic kidney disease among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Trulance. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

On Jul, 10, 2026

63 people who take Protonix and Trulance together, and have interactions are studied.

Protonix and Trulance drug interactions.

What are the common drug interactions of Protonix and Trulance, by gender? *:

female:

Chronic kidney disease
Migraine (headache)
Fatigue (feeling of tiredness)
Pain
Arthralgia (joint pain)
Asthma
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Device occlusion
Hereditary angioedema (recurrent episodes of severe swelling)
Infusion related reaction

male:

Diarrhoea
Abdominal distension
Disease recurrence
Abdominal pain
Constipation
Pneumonia
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Vomiting

What are the common drug interactions of Protonix and Trulance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fall
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypersensitivity
Hypertension (high blood pressure)

40-49:

Arthralgia (joint pain)
Asthma
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Device occlusion
Dizziness
Ear congestion
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)
Hereditary angioedema (recurrent episodes of severe swelling)

50-59:

Diarrhoea
Abdominal distension
Disease recurrence
Anxiety
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Body temperature increased
Bowen's disease (early stage of skin cancer)
Chest pain
Chills (felling of cold)

60+:

Chronic kidney disease
Constipation
Abdominal pain
Blood pressure decreased
Feeling jittery
Heart rate increased
Nausea (feeling of having an urge to vomit)
Pneumonia
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 20 people, 31.75%
Constipation: 11 people, 17.46%
Asthma: 8 people, 12.70%
High Blood Pressure: 7 people, 11.11%
Immune System Disorder: 6 people, 9.52%
B-Lymphocyte Abnormalities (abnormal population of b lymphocytes in the blood, bone marrow, or tissues): 6 people, 9.52%
Pain: 5 people, 7.94%
Neuropathy Peripheral (surface nerve damage): 4 people, 6.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 6.35%
Irritable Bowel Syndrome: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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