Provera and Claravis drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Claravis (isotretinoin). Common drug interactions include unintended pregnancy among females.
The phase IV clinical study analyzes what interactions people have when they take Provera and Claravis. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.
What is Provera?
Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.
What is Claravis?
Claravis has active ingredients of isotretinoin. It is often used in acne. eHealthMe is studying from 9,636 Claravis users. Check the latest studies of Claravis.
32 people who take Provera and Claravis together, and have interactions are studied.

What are the common drug interactions of Provera and Claravis, by gender? *:
female:
- Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
- Dry skin
- Abortion induced (medically referred abortion)
- Maternal exposure during pregnancy (use of substance during pregnancy)
- Pregnancy with injectable contraceptive
- Abortion spontaneous (naturally occurring miscarriage)
- Arthralgia (joint pain)
- Emotional distress
- Epistaxis (bleed from the nose)
- Proctitis ulcerative (inflammation of the rectum and anus ulcerative)
male:
n/a
What are the common drug interactions of Provera and Claravis, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
- Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
- Abortion induced (medically referred abortion)
- Drug exposure during pregnancy
- Arthralgia (joint pain)
- Dry skin
- Emotional distress
- Epistaxis (bleed from the nose)
- Inflammatory bowel disease
- Proctitis ulcerative (inflammation of the rectum and anus ulcerative)
- Suicide attempt
20-29:
- Inflammatory bowel disease
- Irritable bowel syndrome
- Urinary tract infection
- Drug exposure during pregnancy
- Maternal exposure during pregnancy (use of substance during pregnancy)
- Abortion induced (medically referred abortion)
- Pregnancy with injectable contraceptive
- Abortion spontaneous (naturally occurring miscarriage)
- Asthenia (weakness)
- Dizziness
30-39:
- Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
- Abortion spontaneous (naturally occurring miscarriage)
- Pulmonary embolism (blockage of the main artery of the lung)
- Vaginal haemorrhage (vaginal bleeding)
40-49:
n/a
50-59:
n/a
60+:
n/a
What are the existing conditions these people have? *
- Pain: 2 people, 6.25%
* Approximation only. Some reports may have incomplete information.
Do you take Provera and Claravis?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Provera and Claravis:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Provera:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Claravis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Provera and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Claravis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
- Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
- Ersoy MA, Ersoy HT, "Manic symptoms associated with isotretinoin and methylphenidate combination: a case report", Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, 2014 Sep .
How the study uses the data?
The study uses data from the FDA. It is based on medroxyprogesterone acetate and isotretinoin (the active ingredients of Provera and Claravis, respectively), and Provera and Claravis (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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