Provera and Tresiba drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Tresiba (insulin degludec). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Provera and Tresiba. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Tresiba?

Tresiba has active ingredients of insulin degludec. It is often used in type 1 diabetes. eHealthMe is studying from 20,677 Tresiba users. Check the latest studies of Tresiba.

On Aug, 08, 2026

22 people who take Provera and Tresiba together, and have interactions are studied.

What are the common drug interactions of Provera and Tresiba, by gender? *:

female:

Chronic kidney disease
Drug ineffective
Nausea (feeling of having an urge to vomit)
Tendon rupture (tear of tendon)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Abdominal pain upper
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hyperglycaemia (high blood sugar)
Joint swelling

male:

n/a

What are the common drug interactions of Provera and Tresiba, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Intestinal obstruction
Abdominal pain upper
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemia (high blood sugar)
Myalgia (muscle pain)
Paranasal sinus hypersecretion
Pulmonary function test decreased
Sinus congestion (blockage of sinus)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Infection

40-49:

Drug ineffective
Joint swelling
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myalgia (muscle pain)
Peripheral swelling
Urethral pain
Vulvovaginal dryness

50-59:

Drug ineffective

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 31.82%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 31.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 27.27%
Pain: 5 people, 22.73%
High Blood Cholesterol: 5 people, 22.73%
Diabetes: 5 people, 22.73%
Depression: 5 people, 22.73%
Cardiac Disorder: 5 people, 22.73%
Blood Pressure Abnormal: 5 people, 22.73%
Sleep Disorder: 4 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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