Provera and Truvada drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Truvada (emtricitabine; tenofovir disoproxil fumarate). Common drug interactions include hip fracture among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Provera and Truvada. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

On Jul, 12, 2026

52 people who take Provera and Truvada together, and have interactions are studied.

What are the common drug interactions of Provera and Truvada, by gender? *:

female:

Hip fracture
Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Fractured sacrum
Joint dislocation (a joint position is changed from normal position)
Joint injury
Nephropathy (damage to or disease of a kidney)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal impairment (severely reduced kidney function)

male:

Diarrhoea
Fatigue (feeling of tiredness)

What are the common drug interactions of Provera and Truvada, by age (0-1 to 60+)? *:

0-1:

Glossodynia (a burning or painful sensation in the tongue)
Pigmentation buccal (darkening of an area of buccal)
Tongue pigmentation (colouring of tongue)

2-9:

n/a

10-19:

n/a

20-29:

Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Blood alkaline phosphatase increased
Blood bilirubin unconjugated increased
Chills (felling of cold)
Conjunctival oedema (conjunctival swelling)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Gangrene (body tissue dies)
Gastritis (inflammation of stomach)

30-39:

Back pain
Blood albumin decreased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Blood phosphorus increased
Blood pressure systolic decreased
Carbon dioxide decreased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Catheter site oedema (swelling at catheter site)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteoporosis (bones weak and more likely to break)
Osteopenia (a condition where bone mineral density is lower than normal)
Chronic kidney disease
Gait disturbance
Lower limb fracture
Bone density decreased

50-59:

n/a

60+:

Application site vesicles (small bubble within a cell at application site)
Catheter site pain
Infusion site pain
Injection site pain
Local swelling (swelling at the site of some application of substance or injury)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Neck pain
Pain

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 11.54%
Depression: 5 people, 9.62%
Anaemia (lack of blood): 5 people, 9.62%
Asthma: 4 people, 7.69%
Hepatitis C: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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