Provera and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Vytorin (ezetimibe; simvastatin). Common drug interactions include breast cancer female among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Provera and Vytorin. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

46 people who take Provera and Vytorin together, and have interactions are studied.

What are the common drug interactions of Provera and Vytorin, by gender? *:

female:

Breast cancer female
Weight fluctuation
Breast cancer
Diarrhoea
Rash
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Gingivitis (inflammation of gums)
Stomatitis (inflammation of mucous membrane of mouth)
Depression suicidal (suicide depressive disorder)

male:

Anxiety
Blood glucose increased
Breast cancer female
Depression
Asthma
Facial pain
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)

What are the common drug interactions of Provera and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activated partial thromboplastin time prolonged
Chest pain
Weight decreased

30-39:

Drug hypersensitivity
Eye pain
Facial pain
Headache (pain in head)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Rhinalgia (pain in the nose)
Sinusitis (inflammation of sinus)
Teething (process by which an infant's first teeth grows)
Throat irritation

40-49:

Depression suicidal (suicide depressive disorder)
Diarrhoea
Rash
Vomiting
Abdominal pain upper
Dyspnoea (difficult or laboured respiration)
Feeling hot
Pruritus (severe itching of the skin)
Swelling
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Breast cancer
Breast cancer stage i
Breast cancer female
Dental care
Gingivitis (inflammation of gums)
Glossodynia (a burning or painful sensation in the tongue)
Stomatitis (inflammation of mucous membrane of mouth)
Weight increased

60+:

Breast cancer female
Diarrhoea
Anaemia postoperative
Atrophic vulvovaginitis (inflammation of the vulva)
Breast cyst
Cervical polyp (tumour on the surface of the cervical canal)
Concussion (short loss of normal brain function in response to a head injury)
Cyst (a closed sac)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fall

What are the existing conditions these people have? *

Quit Smoking: 7 people, 15.22%
Depression: 7 people, 15.22%
Insomnia (sleeplessness): 5 people, 10.87%
Diabetes: 5 people, 10.87%
Menopause (end of monthly cycles in women): 4 people, 8.70%
Menopausal Symptoms: 4 people, 8.70%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 8.70%
High Blood Pressure: 4 people, 8.70%
Weight Loss: 3 people, 6.52%
Type 2 Diabetes: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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