Provera and Xeloda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Xeloda (capecitabine). Common drug interactions include pain among females and angina unstable among males.

The phase IV clinical study analyzes what interactions people have when they take Provera and Xeloda. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Xeloda?

Xeloda has active ingredients of capecitabine. It is often used in colon cancer. eHealthMe is studying from 46,649 Xeloda users. Check the latest studies of Xeloda.

On Jul, 13, 2026

43 people who take Provera and Xeloda together, and have interactions are studied.

What are the common drug interactions of Provera and Xeloda, by gender? *:

female:

Pain
Osteonecrosis of jaw (death of bone of jaw)
Urinary tract infection
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Osteomyelitis (infection of bone)
Dyspnoea (difficult or laboured respiration)
Anxiety
Vomiting
Constipation
Headache (pain in head)

male:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Balance disorder
Biliary colic
Bone disorder
Bone swelling
Breath sounds absent
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bruxism (habitual grinding of the teeth, typically during sleep)

What are the common drug interactions of Provera and Xeloda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Constipation
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Bone disorder
Dizziness
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Infection
Oedema peripheral (superficial swelling)

30-39:

Dyspnoea (difficult or laboured respiration)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Renal failure chronic (long lasting kidney dysfunction)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase nos increased
Blood bilirubin increased
Oedema (fluid collection in tissue)
Weakness

40-49:

Myocarditis (inflammation of heart muscle myocardium)
Pyrexia (fever)
Urinary tract infection
Uveitis (inflammation of the uvea)

50-59:

Impaired healing
Pain
Atelectasis (partial or complete collapse of the lung)
Dizziness
Neutropenia (an abnormally low number of neutrophils)
Oral discomfort (pain or irritation in mouth)
Osteonecrosis of jaw (death of bone of jaw)
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Diarrhoea
Gingivitis (inflammation of gums)

60+:

Osteonecrosis (death of bone)
Dizziness
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Haematocrit decreased
Haemoglobin decreased
Lymphadenopathy (disease or enlargement of lymph nodes)
Malignant neoplasm progression (cancer tumour came back)
Metastases to bone (cancer spreads to bone)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 16 people, 37.21%
Fever: 9 people, 20.93%
Respiratory Tract Infection: 8 people, 18.60%
High Blood Pressure: 8 people, 18.60%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 18.60%
Dyspnea (difficult or laboured breathing): 8 people, 18.60%
Renal Cell Carcinoma (a kidney cancer): 8 people, 18.60%
High Blood Cholesterol: 8 people, 18.60%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 18.60%
Oedema (fluid collection in tissue): 8 people, 18.60%

* Approximation only. Some reports may have incomplete information.

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