Provigil and Acetylcysteine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Acetylcysteine (acetylcysteine). Common drug interactions include suicidal ideation among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Acetylcysteine. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Acetylcysteine?

Acetylcysteine has active ingredients of acetylcysteine. It is often used in cough. eHealthMe is studying from 11,563 Acetylcysteine users. Check the latest studies of Acetylcysteine.

On Jul, 06, 2026

20 people who take Provigil and Acetylcysteine together, and have interactions are studied.

Provigil and Acetylcysteine drug interactions.

What are the common drug interactions of Provigil and Acetylcysteine, by gender? *:

female:

Suicidal ideation
Acne (skin problems that cause pimples)
Asthenia (weakness)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug hypersensitivity
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Limb discomfort (discomfort in leg)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

Arthralgia (joint pain)
Burning sensation
Cerebral haematoma (collection of blood in brain)
Cerebral haemorrhage (bleeding within the brain)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coma (state of unconsciousness lasting more than six hours)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Provigil and Acetylcysteine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Benign prostatic hyperplasia (benign enlargement of the prostate)
Calcinosis (calcium deposits in any soft tissue)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Hospitalisation
Nerve compression
Vitamin d deficiency

40-49:

Asthenia (weakness)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Limb discomfort (discomfort in leg)
Micturition urgency (urgency to pass the urine)

50-59:

Blood potassium decreased
Epistaxis (bleed from the nose)
Muscle spasms (muscle contraction)

60+:

Arthralgia (joint pain)
Burning sensation
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall
Gait disturbance
Nausea (feeling of having an urge to vomit)
Osteonecrosis (death of bone)
Pain
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 4 people, 20.00%
Drowsiness: 4 people, 20.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 15.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 15.00%
Blood Potassium Abnormal: 3 people, 15.00%
Blood Pressure Abnormal: 3 people, 15.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 15.00%
Depression: 3 people, 15.00%
Enlarged Prostate: 3 people, 15.00%
Stress And Anxiety: 3 people, 15.00%

* Approximation only. Some reports may have incomplete information.

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