Provigil and Actemra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Actemra (tocilizumab). Common drug interactions include tendon rupture among females and gastroenteritis viral among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Actemra. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Actemra?

Actemra has active ingredients of tocilizumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 102,759 Actemra users. Check the latest studies of Actemra.

On Jul, 13, 2026

33 people who take Provigil and Actemra together, and have interactions are studied.

What are the common drug interactions of Provigil and Actemra, by gender? *:

female:

Tendon rupture (tear of tendon)
Joint stiffness
Malaise (a feeling of general discomfort or uneasiness)
Drug hypersensitivity
Muscle spasms (muscle contraction)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Erythema of eyelid (redness of the eyelid)
Eye swelling
Eyelid pain
Fibromyalgia (a long-term condition which causes pain all over the body)

male:

Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

What are the common drug interactions of Provigil and Actemra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Erythema of eyelid (redness of the eyelid)
Eye swelling
Eyelid pain
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Joint stiffness
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Body mass index increased
Depression
Drug hypersensitivity
Drug ineffective
Gastric disorder (disease of stomach)
Muscle spasms (muscle contraction)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Surgery
Fluid retention (an abnormal accumulation of fluid in the blood)
Pain

60+:

Nausea (feeling of having an urge to vomit)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Joint range of motion decreased (disease of joint movement)
Blood creatinine increased
Drug effect decreased
Feeling hot
Flushing (the warm, red condition of human skin)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Fibula fracture
Interstitial lung disease

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 15.15%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 12.12%
Rashes (redness): 4 people, 12.12%
Pain: 4 people, 12.12%
Neck Pain: 4 people, 12.12%
Nausea And Vomiting: 4 people, 12.12%
Migraine (headache): 4 people, 12.12%
Itching: 4 people, 12.12%
Headache (pain in head): 4 people, 12.12%
Fatigue (feeling of tiredness): 4 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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