Prozac and Brexpiprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Brexpiprazole (brexpiprazole). Common drug interactions include weight decreased among females and agitation among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Brexpiprazole. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Brexpiprazole?

Brexpiprazole has active ingredients of brexpiprazole. eHealthMe is studying from 1,164 Brexpiprazole users. Check the latest studies of Brexpiprazole.



On Jul, 19, 2026

13 people who take Prozac and Brexpiprazole together, and have interactions are studied.

Prozac and Brexpiprazole drug interactions.

What are the common drug interactions of Prozac and Brexpiprazole, by gender? *:

female:

  1. Weight decreased
  2. Weight increased
  3. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
  4. Aggression
  5. Ankle fracture
  6. Arthralgia (joint pain)
  7. Back pain
  8. Bone density decreased
  9. Bone loss
  10. Chronic kidney disease

male:

  1. Agitation (state of anxiety or nervous excitement)
  2. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  3. Suicidal ideation

What are the common drug interactions of Prozac and Brexpiprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Suicide attempt
  2. Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

  1. Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
  2. Hallucination, auditory (perceiving sounds without auditory stimulus)
  3. Neutropenia (an abnormally low number of neutrophils)
  4. Panic attack

30-39:

  1. Emotional disorder
  2. Lymphoma (cancer that begins in immune system cells)
  3. Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  4. Panic attack
  5. Premature rupture of membranes
  6. Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

  1. Weight increased
  2. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
  3. Anger
  4. Autophobia (extreme dislike of oneself)
  5. Binge eating (pattern of disordered eating which consists of episodes of uncontrollable eating)
  6. Drug dependence
  7. Mood swings (an extreme or rapid change in mood)
  8. Nausea (feeling of having an urge to vomit)
  9. Parasomnia (sleep disorders that involve abnormal and unnatural movements, behaviours, emotions, perceptions)
  10. Weight decreased

50-59:

n/a

60+:

  1. Agitation (state of anxiety or nervous excitement)
  2. Suicidal ideation

What are the existing conditions these people have? *

  1. Stress And Anxiety: 3 people, 23.08%
  2. Immunodeficiency Common Variable: 2 people, 15.38%
  3. Hiv Infection: 2 people, 15.38%
  4. Borderline Personality Disorder: 2 people, 15.38%
  5. Bipolar Disorder (mood disorder): 2 people, 15.38%
  6. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.69%
  7. Post-Traumatic Stress Disorder: 1 person, 7.69%
  8. Neuralgia (pain in one or more nerves): 1 person, 7.69%
  9. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 7.69%
  10. Fainting (loss of consciousness and postural tone): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prozac and Brexpiprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prozac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Brexpiprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prozac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Brexpiprazole and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride and brexpiprazole (the active ingredients of Prozac and Brexpiprazole, respectively), and Prozac and Brexpiprazole (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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