Prozac and Indocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Indocin (indomethacin). Common drug interactions include fall among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Indocin. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Indocin?

Indocin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 4,559 Indocin users. Check the latest studies of Indocin.

On Jul, 16, 2026

86 people who take Prozac and Indocin together, and have interactions are studied.

What are the common drug interactions of Prozac and Indocin, by gender? *:

female:

Fall
Dizziness
Spinal osteoarthritis (joint cartilage loss in spine)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Breast cancer
Breast pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone loss
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Deformity (disfigurement)

What are the common drug interactions of Prozac and Indocin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

20-29:

Pulmonary embolism (blockage of the main artery of the lung)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Dyspnoea (difficult or laboured respiration)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Neuropathy peripheral (surface nerve damage)
Painful respiration
Pulmonary thrombosis (scarring in the lungs)
Weight decreased

30-39:

Weight increased
Drug hypersensitivity
Dysarthria (speech disorder)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait abnormal
Gastric disorder (disease of stomach)
Hospitalisation
Rash erythematous (redness of the skin)
Thinking abnormal
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Headache (pain in head)
Weight decreased
Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Muscle spasms (muscle contraction)
Vomiting
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Disturbance in attention
Dysphagia (a condition in which swallowing is difficult or painful)

50-59:

Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Breast cancer
Breast pain
Bursitis infective staphylococcal (staphylococcal infection of the subacromial/subdeltoid bursa)
Cellulitis (infection under the skin)
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Death
Renal injury (kidney injury)
Arthralgia (joint pain)
Balance disorder
Bone pain
Dysphonia (speech disorder attributable to a disorder of phonation)
Emotional distress
Erythema (redness of the skin)
Fear

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 10.47%
Metastases To Bone (cancer spreads to bone): 8 people, 9.30%
Headache (pain in head): 8 people, 9.30%
Metastases To Prostate (cancer spreads to prostate): 7 people, 8.14%
Menopause (end of monthly cycles in women): 7 people, 8.14%
Stress And Anxiety: 5 people, 5.81%
Bipolar Disorder (mood disorder): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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