Psyllium and Hctz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Psyllium (blond psyllium) and Hctz (hydrochlorothiazide). Common drug interactions include fatigue among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Psyllium and Hctz. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Psyllium?

Psyllium has active ingredients of blond psyllium. It is often used in constipation. eHealthMe is studying from 4,262 Psyllium users. Check the latest studies of Psyllium.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

32 people who take Psyllium and Hctz together, and have interactions are studied.

What are the common drug interactions of Psyllium and Hctz, by gender? *:

female:

Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Abdominal pain
Fall
Injury
Insomnia (sleeplessness)
Irritable bowel syndrome
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain

male:

Pain
Memory impairment
Hospitalisation
Hypercreatininaemia (high levels of creatine in the blood)
Osteoporosis (bones weak and more likely to break)
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal disorder (kidney disease)
Scab (a hard coating on the skin formed during the wound healing)
Skin discolouration (change of skin colour)
Sneezing

What are the common drug interactions of Psyllium and Hctz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Erythema (redness of the skin)
Fall
Headache (pain in head)
Hepatic enzyme increased
Jc virus test positive

50-59:

Myalgia (muscle pain)
Pain
Angioedema (rapid swelling of the dermis)
Dysphonia (speech disorder attributable to a disorder of phonation)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Post procedural haemorrhage (post procedural bleeding)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

60+:

Fatigue (feeling of tiredness)
Pain
Insomnia (sleeplessness)
Irritable bowel syndrome
Osteoporosis (bones weak and more likely to break)
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal disorder (kidney disease)
Scab (a hard coating on the skin formed during the wound healing)
Skin discolouration (change of skin colour)
Tooth loss

What are the existing conditions these people have? *

Drowsiness: 7 people, 21.88%
Depression: 3 people, 9.38%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.25%
Irritable Bowel Syndrome: 2 people, 6.25%
Hiv Infection: 2 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.25%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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