Pyrimethamine and Morphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyrimethamine (pyrimethamine) and Morphine (morphine sulfate). Common drug interactions include diarrhoea among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Pyrimethamine and Morphine. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Pyrimethamine?

Pyrimethamine has active ingredients of pyrimethamine. eHealthMe is studying from 1,514 Pyrimethamine users. Check the latest studies of Pyrimethamine.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

On Aug, 10, 2026

41 people who take Pyrimethamine and Morphine together, and have interactions are studied.

Pyrimethamine and Morphine drug interactions.

What are the common drug interactions of Pyrimethamine and Morphine, by gender? *:

female:

Diarrhoea
Enterobacter bacteraemia (enterobacter cloacae are nosocomial pathogens that can cause a range of infections such as bacteraemia, lower respiratory tract infection, skin)
Hyperbilirubinaemia (excess of bilirubin in the blood)
International normalised ratio decreased
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Heart rate increased
Respiratory rate increased (excess breathing rate/min)
Anaemia (lack of blood)

male:

Headache (pain in head)
Dyskinesia (abnormality or impairment of voluntary movement)
Blood cholesterol increased
Muscular weakness (muscle weakness)
Weight increased
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Complex partial seizures (epileptic seizure)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Pupils unequal

What are the common drug interactions of Pyrimethamine and Morphine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anxiety disorder
Back disorder
Communication disorder (speech and language disorder)
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Crying
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyskinesia (abnormality or impairment of voluntary movement)
Eye infection toxoplasmal (a germ called toxoplasma can cause infection within the eye)
Headache (pain in head)
Memory impairment

20-29:

n/a

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cytomegalovirus chorioretinitis (infection of choroid and retina of the eye from virus)
Diabetes insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function)
Disease progression
Drug ineffective
Electrocardiogram qt prolonged
Emotional distress
Encephalitis herpes (inflammation of the brain due to herpes infection)
Enterobacter bacteraemia (enterobacter cloacae are nosocomial pathogens that can cause a range of infections such as bacteraemia, lower respiratory tract infection, skin)
Hepatic steatosis (fatty liver disease)

40-49:

Blood cholesterol increased
Weight increased
Oedema (fluid collection in tissue)
Heart rate increased
Respiratory rate increased (excess breathing rate/min)
Adenocarcinoma pancreas (cancer of pancreas)
Csf protein increased
Diarrhoea
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)

50-59:

Arthralgia (joint pain)
Asthenia (weakness)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chills (felling of cold)
Cough
Drug dependence
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Herpes zoster

60+:

Anaemia (lack of blood)
Cardiogenic shock (inadequate circulation of blood)
Electrocardiogram st segment elevation
Leukoencephalopathy (disease of the white matter in the brain)
Meningitis bacterial (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mycobacterium avium complex infection
Tongue biting
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)

What are the existing conditions these people have? *

Hiv Infection: 30 people, 73.17%
Toxoplasmosis (a parasitic disease caused by the protozoan toxoplasma gondii): 15 people, 36.59%
Agitation (state of anxiety or nervous excitement): 15 people, 36.59%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 7.32%
Joint Pain: 3 people, 7.32%
Erection Problems: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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