Quetiapine fumarate and Epival drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Quetiapine fumarate (quetiapine fumarate) and Epival (divalproex sodium). Common drug interactions include hypomania among females and mental impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Quetiapine fumarate and Epival. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Quetiapine fumarate?

Quetiapine fumarate has active ingredients of quetiapine fumarate. It is often used in insomnia. eHealthMe is studying from 29,526 Quetiapine fumarate users. Check the latest studies of Quetiapine fumarate.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

On Jul, 09, 2026

25 people who take Quetiapine fumarate and Epival together, and have interactions are studied.

Quetiapine fumarate and Epival drug interactions.

What are the common drug interactions of Quetiapine Fumarate and Epival, by gender? *:

female:

Hypomania (a mild form of mania, marked by elation and hyperactivity)
Psychotic disorder
Blood bilirubin increased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hepatic enzyme increased
Hepatotoxicity (chemical-driven liver damage)
Jaundice cholestatic
Nausea (feeling of having an urge to vomit)
Pneumonia
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)

male:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Anxiety
B-cell lymphoma (blood cancer affecting b cells)
Bone pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Essential tremor
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)

What are the common drug interactions of Quetiapine Fumarate and Epival, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Anxiety
Depressed mood
Irritability
Mood swings (an extreme or rapid change in mood)
Vomiting
General physical health deterioration (weak health status)

30-39:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

40-49:

Asthma
B-cell lymphoma (blood cancer affecting b cells)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bone pain
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug ineffective
Essential tremor
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)

50-59:

Blood bilirubin increased
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Vomiting
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Cardiac murmur (an heart sound in valve abnormality)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lung neoplasm malignant (cancer tumour of lung)
Nasal polyps (masses that develop in the lining of the nose)
Oedema peripheral (superficial swelling)

60+:

Granulocytopenia (lack of granulocyte)

What are the existing conditions these people have? *

Psychotic Disorder: 15 people, 60.00%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 15 people, 60.00%
Depression: 15 people, 60.00%
Hiv Infection: 14 people, 56.00%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 11 people, 44.00%
Pain In Extremity: 7 people, 28.00%
Affective Disorder (mental disorder): 3 people, 12.00%
Bipolar Disorder (mood disorder): 2 people, 8.00%
Autism Spectrum Disorder (developmental disabilities that can cause significant social, communication and behavioural challenges): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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