Rabeprazole sodium and Aprepitant drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rabeprazole sodium (rabeprazole sodium) and Aprepitant (aprepitant). Common drug interactions include restless legs syndrome among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Rabeprazole sodium and Aprepitant. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Rabeprazole sodium?

Rabeprazole sodium has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 15,786 Rabeprazole sodium users. Check the latest studies of Rabeprazole sodium.

What is Aprepitant?

Aprepitant has active ingredients of aprepitant. eHealthMe is studying from 6,992 Aprepitant users. Check the latest studies of Aprepitant.

On Jul, 26, 2026

48 people who take Rabeprazole sodium and Aprepitant together, and have interactions are studied.

Rabeprazole sodium and Aprepitant drug interactions.

What are the common drug interactions of Rabeprazole Sodium and Aprepitant, by gender? *:

female:

Restless legs syndrome (a powerful urge to move your legs)
Restlessness (not able to rest)
Acute respiratory distress syndrome
Back pain
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Myelosuppression (a decrease in the production of blood cells)
Febrile neutropenia (fever with reduced white blood cells)
Alanine aminotransferase increased
Aspartate aminotransferase increased

male:

Pneumonia
White blood cell count decreased
Dyspnoea (difficult or laboured respiration)
Enteritis (inflammation of the small intestine)
Gastritis (inflammation of stomach)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Herpes zoster
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Rabeprazole Sodium and Aprepitant, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Ichthyosis acquired (acquired skin disorders)
Psoriasis (immune-mediated disease that affects the skin)
Subcutaneous abscess

40-49:

Interstitial lung disease
Lung disorder (lung disease)
Dysphonia (speech disorder attributable to a disorder of phonation)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Pyrexia (fever)
Rash
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Back pain
Abdominal distension
Cardiac failure
Chest discomfort
Chest pain
Colitis (inflammation of colon)
Constipation
Dermatitis allergic (inflammation of the skin due allergic reaction)
Dyspnoea (difficult or laboured respiration)

60+:

Myelosuppression (a decrease in the production of blood cells)
Febrile neutropenia (fever with reduced white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Platelet count decreased
Pneumonia
Cytomegalovirus infection
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Abdominal pain
Adrenal disorder

What are the existing conditions these people have? *

Constipation: 18 people, 37.50%
High Blood Pressure: 15 people, 31.25%
Nausea (feeling of having an urge to vomit): 10 people, 20.83%
Insomnia (sleeplessness): 10 people, 20.83%
Non-Small Cell Lung Cancer Stage Iv: 9 people, 18.75%
Gastritis (inflammation of stomach): 8 people, 16.67%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 8 people, 16.67%
Fever: 8 people, 16.67%
Rash Maculo-Papular (red area on the skin that is covered with small confluent bumps): 7 people, 14.58%
Burkitt Lymphoma (cancer of the lymphatic system): 7 people, 14.58%

* Approximation only. Some reports may have incomplete information.

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