Mirena and Zolpidem drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Mirena (levonorgestrel) and Zolpidem (zolpidem tartrate). Common drug interactions include drug ineffective among females.
The phase IV clinical study analyzes what interactions people have when they take Mirena and Zolpidem. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.
What is Mirena?
Mirena has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 145,266 Mirena users. Check the latest studies of Mirena.
What is Zolpidem?
Zolpidem has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 92,695 Zolpidem users. Check the latest studies of Zolpidem.
68 people who take Mirena and Zolpidem together, and have interactions are studied.

What are the common drug interactions of Mirena and Zolpidem, by gender? *:
female:
- Drug ineffective
- Pain
- Liver injury
- Nasopharyngitis (inflammation of the nasopharynx)
- Back pain
- Colon cancer recurrent
- Device dislocation
- Weight increased
- Dyspareunia (painful sexual intercourse)
- Seasonal allergy (allergic condition due to certain season)
male:
n/a
What are the common drug interactions of Mirena and Zolpidem, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Drug ineffective
- Liver injury
- Pain
- Procedural pain
- Abdominal pain upper
- Blepharospasm (any abnormal contraction or twitch of the eyelid)
- Increased appetite
- Injury
- Muscle disorder (muscle disease)
- Muscle spasms (muscle contraction)
30-39:
- Arteriosclerosis (thickening and hardening of arteries)
- Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
- Arthralgia (joint pain)
- Arthritis (form of joint disorder that involves inflammation of one or more joints)
- Asthenia (weakness)
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Bone deformity
- Bone fragmentation
- Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
- Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
40-49:
- Contusion (a type of hematoma of tissue in which capillaries)
- Diarrhoea
- Dyspareunia (painful sexual intercourse)
- Nausea (feeling of having an urge to vomit)
- Procedural pain
- Benign breast neoplasm (benign (non-cancerous) tumours of the breast)
- Bone tuberculosis
- Hypomenorrhoea (a diminution of the menstrual flow or a shortening of the duration of menstruation)
- Menstruation irregular
- Abdominal pain lower
50-59:
- Anxiety
- Depression
- Uterine haemorrhage (uterine bleeding)
- Abdominal pain
- Abdominal pain lower
- Affective disorder (mental disorder)
- Appetite disorder (abnormal eating habits)
- Asthenia (weakness)
- Back pain
- Breast cancer
60+:
n/a
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 19.12%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 19.12%
- Migraine (headache): 9 people, 13.24%
- Sleep Disorder: 8 people, 11.76%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 8.82%
- Immunodeficiency Common Variable: 6 people, 8.82%
- Drowsiness: 6 people, 8.82%
- Neuralgia (pain in one or more nerves): 4 people, 5.88%
- Abdominal Pain Upper: 4 people, 5.88%
* Approximation only. Some reports may have incomplete information.
Do you take Mirena and Zolpidem?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Mirena and Zolpidem:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Mirena:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Zolpidem:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Mirena and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zolpidem and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
- Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
- Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
- Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .
- Hsu FG, Sheu MJ, Lin CL, Hsieh YW, Lai SW, "Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan", The Journal of Clinical Pharmacology, 2017 Mar .
- Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
- Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH, "Association between zolpidem and suicide: a nationwide population-based case-control study", InMayo Clinic Proceedings, 2016 Mar .
- Liao KF, Lin CL, Lai SW, Chen WC, "Zolpidem use associated with increased risk of pyogenic liver abscess: a case-control study in Taiwan", Medicine, 2015 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on levonorgestrel and zolpidem tartrate (the active ingredients of Mirena and Zolpidem, respectively), and Mirena and Zolpidem (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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