Ramelteon and Clonidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ramelteon (ramelteon) and Clonidine (clonidine). Common drug interactions include diarrhoea among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Ramelteon and Clonidine. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Ramelteon?

Ramelteon has active ingredients of ramelteon. It is often used in insomnia. eHealthMe is studying from 1,387 Ramelteon users. Check the latest studies of Ramelteon.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

20 people who take Ramelteon and Clonidine together, and have interactions are studied.

Ramelteon and Clonidine drug interactions.

What are the common drug interactions of Ramelteon and Clonidine, by gender? *:

female:

Diarrhoea
Blood pressure decreased
Chronic kidney disease
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Death
Feeling hot
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hyperhidrosis (abnormally increased sweating)
Influenza
Irritability

male:

Chronic kidney disease
Acidosis (build-up of carbon dioxide in the blood)
Hyperhidrosis (abnormally increased sweating)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal tubular necrosis (death of kidney tubules)
Sensory disturbance (sense disturbance)
Temperature regulation disorder (body is unable to maintain temperature)
Drug ineffective
Hypokalaemia (low potassium)

What are the common drug interactions of Ramelteon and Clonidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Diarrhoea
Blood pressure decreased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Influenza
Irritability
Retching (strong involuntary effort to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vomiting

10-19:

Drug ineffective

20-29:

Drooling (drop saliva uncontrollably from the mouth)

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

n/a

60+:

Acidosis (build-up of carbon dioxide in the blood)
Chronic kidney disease
Diarrhoea
Feeling hot
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Renal tubular necrosis (death of kidney tubules)
Rhinorrhoea (watery mucus discharge from the nose)
Sensory disturbance (sense disturbance)
Temperature regulation disorder (body is unable to maintain temperature)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 20.00%
Tardive Dyskinesia (a disorder that involves involuntary movements): 2 people, 10.00%
Aggression: 2 people, 10.00%
Sleep Disorder: 1 person, 5.00%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 1 person, 5.00%
Renal Disorder (kidney disease): 1 person, 5.00%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.00%
Mood Swings (an extreme or rapid change in mood): 1 person, 5.00%
Irregular Sleep Phase: 1 person, 5.00%
Stress And Anxiety: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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