Ramipril and Zonegran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ramipril (ramipril) and Zonegran (zonisamide). Common drug interactions include burning sensation among females and ear injury among males.

The phase IV clinical study analyzes what interactions people have when they take Ramipril and Zonegran. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Ramipril?

Ramipril has active ingredients of ramipril. It is often used in high blood pressure. eHealthMe is studying from 147,398 Ramipril users. Check the latest studies of Ramipril.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 01, 2026

17 people who take Ramipril and Zonegran together, and have interactions are studied.

Ramipril and Zonegran drug interactions.

What are the common drug interactions of Ramipril and Zonegran, by gender? *:

female:

  1. Burning sensation
  2. Dehydration (dryness resulting from the removal of water)
  3. Erythema (redness of the skin)
  4. Flatulence (flatus expelled through the anus)
  5. Fungal infection
  6. Heart rate irregular
  7. Hypersensitivity
  8. Laceration (tearing of soft body tissue)
  9. Muscle spasms (muscle contraction)
  10. Nephrolithiasis (calculi in the kidneys)

male:

  1. Ear injury
  2. Jaw fracture
  3. Erysipelas (bacterial skin infection)
  4. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  5. Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
  6. Partial seizures (seizures which affect only a part of the brain at onset)
  7. Abnormal dreams
  8. Brain stem haemorrhage (bleeding into structures of brain stem)
  9. Cerebral haematoma (collection of blood in brain)
  10. Cerebral haemorrhage (bleeding within the brain)

What are the common drug interactions of Ramipril and Zonegran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Hallucination, auditory (perceiving sounds without auditory stimulus)
  2. Insomnia (sleeplessness)
  3. Drug ineffective
  4. Pain

50-59:

  1. Ear injury
  2. Jaw fracture
  3. Skin injury
  4. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

  1. Aggression
  2. Delusional disorder, unspecified type
  3. Grand mal convulsion (a type of generalized seizure that affects the entire brain)
  4. Personality change
  5. Postictal state
  6. Speech disorder
  7. Tremor (trembling or shaking movements in one or more parts of your body)
  8. Urinary incontinence (inability to control the flow of urine and involuntary urination)
  9. Visual impairment
  10. Vitamin b12 deficiency

What are the existing conditions these people have? *

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 29.41%
  2. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 23.53%
  3. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 17.65%
  4. Partial Seizures (seizures which affect only a part of the brain at onset): 3 people, 17.65%
  5. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 11.76%
  6. Rickets (softening of bones): 2 people, 11.76%
  7. Type 2 Diabetes: 2 people, 11.76%
  8. Insomnia (sleeplessness): 1 person, 5.88%
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 5.88%
  10. Diabetes: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Ramipril and Zonegran?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ramipril and Zonegran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ramipril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zonegran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ramipril and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zonegran and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ramipril and zonisamide (the active ingredients of Ramipril and Zonegran, respectively), and Ramipril and Zonegran (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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