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Ranitidine hydrochloride and Amitiza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranitidine hydrochloride (ranitidine hydrochloride) and Amitiza (lubiprostone). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Ranitidine hydrochloride and Amitiza. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Ranitidine hydrochloride?

Ranitidine hydrochloride has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 76,413 Ranitidine hydrochloride users. Check the latest studies of Ranitidine hydrochloride.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

On Jul, 19, 2026

32 people who take Ranitidine hydrochloride and Amitiza together, and have interactions are studied.

Ranitidine hydrochloride and Amitiza drug interactions.

What are the common drug interactions of Ranitidine Hydrochloride and Amitiza, by gender? *:

female:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Renal injury (kidney injury)
  4. Blood glucose decreased
  5. Connective tissue disorder (any disease that has the connective tissues of the body)
  6. Fatigue (feeling of tiredness)
  7. Headache (pain in head)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Nausea (feeling of having an urge to vomit)
  10. Premature delivery

male:

  1. Chronic kidney disease
  2. Pyrexia (fever)
  3. Influenza
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Nephrogenic anaemia (anaemia due to kidney disease)
  6. Oedema peripheral (superficial swelling)
  7. Renal cancer (cancer of kidney)
  8. Renal failure (kidney dysfunction)
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)

What are the common drug interactions of Ranitidine Hydrochloride and Amitiza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Blood glucose decreased
  2. Blood glucose increased

30-39:

n/a

40-49:

  1. Chronic kidney disease
  2. Chills (felling of cold)
  3. Diarrhoea
  4. Faecal incontinence (a lack of control over passing stool)
  5. Fatigue (feeling of tiredness)
  6. Hyperhidrosis (abnormally increased sweating)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Nausea (feeling of having an urge to vomit)
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Vomiting

50-59:

  1. Chronic kidney disease
  2. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  3. Nephrogenic anaemia (anaemia due to kidney disease)
  4. Headache (pain in head)
  5. Renal cancer (cancer of kidney)
  6. Renal failure (kidney dysfunction)
  7. Renal injury (kidney injury)
  8. Weight increased

60+:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Dehydration (dryness resulting from the removal of water)
  4. Diarrhoea
  5. Dizziness
  6. Drug ineffective
  7. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  8. Dry mouth
  9. Dyspepsia (indigestion)
  10. Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

  1. High Blood Pressure: 9 people, 28.12%
  2. High Blood Cholesterol: 8 people, 25.00%
  3. Pain: 8 people, 25.00%
  4. Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 21.88%
  5. Depression: 7 people, 21.88%
  6. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 15.62%
  7. Blood Pressure Abnormal: 4 people, 12.50%
  8. Nausea (feeling of having an urge to vomit): 4 people, 12.50%
  9. Diabetes: 4 people, 12.50%
  10. Asthma: 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Ranitidine hydrochloride and Amitiza?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ranitidine hydrochloride and Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ranitidine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ranitidine hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amitiza and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride and lubiprostone (the active ingredients of Ranitidine hydrochloride and Amitiza, respectively), and Ranitidine hydrochloride and Amitiza (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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