Ranitidine hydrochloride and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranitidine hydrochloride (ranitidine hydrochloride) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include musculoskeletal pain among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Ranitidine hydrochloride and Flexeril. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Ranitidine hydrochloride?

Ranitidine hydrochloride has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 76,413 Ranitidine hydrochloride users. Check the latest studies of Ranitidine hydrochloride.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 14, 2026

67 people who take Ranitidine hydrochloride and Flexeril together, and have interactions are studied.

Ranitidine hydrochloride and Flexeril drug interactions.

What are the common drug interactions of Ranitidine Hydrochloride and Flexeril, by gender? *:

female:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cough
Emotional distress
Fall
Fatigue (feeling of tiredness)
Fractured sacrum
Gait disturbance
Heart rate increased
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Asthenia (weakness)
Diarrhoea
Cellulitis (infection under the skin)
Confusional state
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Fall
Groin abscess (pus in groin)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intervertebral disc degeneration (spinal disc degeneration)

What are the common drug interactions of Ranitidine Hydrochloride and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Scar
Acute sinusitis
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthropathy
Bone disorder
Bone loss

10-19:

n/a

20-29:

Drug screen positive
Normal newborn
Blood creatine phosphokinase increased
Brain hypoxia (reduced supply of oxygen to the brain)
Cardiac arrest
Coma (state of unconsciousness lasting more than six hours)
Dizziness
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Loss of consciousness
Muscle rigidity (muscle stiffness)

30-39:

Anxiety
Diarrhoea
Abdominal distension
Axillary vein thrombosis (formation of a blood clot in axillary vein)
Cholecystitis chronic (long lasting infection of gallbladder)
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Dyspepsia (indigestion)
Flatulence (flatus expelled through the anus)

40-49:

Asthma
Blood pressure increased
Dizziness
Erythema (redness of the skin)
Eye swelling
Fatigue (feeling of tiredness)
Heart rate increased
Hysterectomy
Photosensitivity reaction
Pruritus (severe itching of the skin)

50-59:

Gastric cancer (stomach cancer)
Renal failure (kidney dysfunction)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Colitis (inflammation of colon)
Cytomegalovirus infection
Drug hypersensitivity
Eye pruritus (eye itching)
Femur fracture
Fibromyalgia (a long-term condition which causes pain all over the body)
Fracture displacement

60+:

Diarrhoea
Cellulitis (infection under the skin)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Discomfort
Dizziness
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear haemorrhage (bleeding from ear)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 20.90%
Stress And Anxiety: 12 people, 17.91%
Pain: 12 people, 17.91%
Multiple Myeloma (cancer of the plasma cells): 10 people, 14.93%
Depression: 9 people, 13.43%
High Blood Pressure: 8 people, 11.94%
Indigestion: 6 people, 8.96%
Sleep Disorder: 5 people, 7.46%
Hypersensitivity: 5 people, 7.46%
High Blood Cholesterol: 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

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