Rebif and Valproic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rebif (interferon beta-1a) and Valproic acid (valproic acid). Common drug interactions include pyuria among females and coma among males.

The phase IV clinical study analyzes what interactions people have when they take Rebif and Valproic acid. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Rebif?

Rebif has active ingredients of interferon beta-1a. It is often used in multiple sclerosis. eHealthMe is studying from 61,126 Rebif users. Check the latest studies of Rebif.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23 people who take Rebif and Valproic acid together, and have interactions are studied.

Rebif and Valproic acid drug interactions.

What are the common drug interactions of Rebif and Valproic Acid, by gender? *:

female:

Pyuria (a condition of urine containing pus)
Restlessness (not able to rest)
Sedation
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress symptoms
Tooth fracture
Tooth infection
Troponin increased
Urinary tract infection
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)

male:

Coma (state of unconsciousness lasting more than six hours)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Hepatotoxicity (chemical-driven liver damage)
Influenza like illness
Joint swelling
Jugular vein thrombosis (clot in jugular vein)
Loss of consciousness
Pain in extremity
Progressive multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord)

What are the common drug interactions of Rebif and Valproic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Coma (state of unconsciousness lasting more than six hours)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Hepatotoxicity (chemical-driven liver damage)
Loss of consciousness
Renal failure (kidney dysfunction)

20-29:

Dizziness
Headache (pain in head)
Loss of consciousness
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)

30-39:

Vasculitis (inflammation of a blood vessel or blood vessels)
Weight decreased
Gait disturbance
Influenza like illness
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Adenomyosis (presence of ectopic glandular tissue found in muscle)
Anaemia (lack of blood)
Anxiety
Arrhythmia (irregular heartbeat)
Blood pressure increased

40-49:

Chills (felling of cold)
Cough
Feeling cold
Headache (pain in head)
Lower respiratory tract infection
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Asthenia (weakness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Alopecia (absence of hair from areas of the body)
Apathy
Aspartate aminotransferase increased
Back pain
Dizziness
Fall
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)

60+:

n/a

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 8 people, 34.78%
Depression: 4 people, 17.39%
Cardiac Disorder: 4 people, 17.39%
Sleep Disorder: 2 people, 8.70%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 2 people, 8.70%
Gait Disturbance: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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