Reclast and Maxalt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reclast (zoledronic acid) and Maxalt (rizatriptan benzoate). Common drug interactions include fall among females.

The phase IV clinical study analyzes what interactions people have when they take Reclast and Maxalt. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.



On Jul, 08, 2026

60 people who take Reclast and Maxalt together, and have interactions are studied.

Reclast and Maxalt drug interactions.

What are the common drug interactions of Reclast and Maxalt, by gender? *:

female:

  1. Fall
  2. Femur fracture
  3. Tibia fracture (fracture of lower leg bone)
  4. Upper limb fracture
  5. Wrist fracture
  6. Radius fracture
  7. Ulna fracture (fracture inside bone)
  8. Electrocardiogram qt prolonged
  9. Spinal cord compression
  10. Gastric ulcer (stomach ulcer)

male:

n/a

What are the common drug interactions of Reclast and Maxalt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Femur fracture
  2. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  3. Depression
  4. Fall
  5. Forearm fracture (fracture in between wrist to elbow)
  6. Gastric ulcer (stomach ulcer)
  7. Gastritis (inflammation of stomach)
  8. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  9. Lower limb fracture
  10. Oesophageal spasm (contraction of oesophagus)

40-49:

  1. Arthralgia (joint pain)
  2. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
  3. Comminuted fracture (bone has broken into several pieces)
  4. Femur fracture
  5. Iatrogenic injury (iatrogenic injury is a form of medical error)
  6. Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
  7. Bone loss
  8. Fall
  9. Gastrointestinal tract irritation
  10. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

  1. B-lymphocyte count decreased
  2. Blood glucose decreased
  3. Blood immunoglobulin a decreased
  4. Blood pressure increased
  5. Cd4 lymphocytes decreased
  6. Chest discomfort
  7. Chills (felling of cold)
  8. Confusional state
  9. Dacryocystitis (inflammation of the lacrimal sac causing obstruction of the tube draining tears into the nose)
  10. Delirium (wild excitement)

60+:

  1. Electrocardiogram qt prolonged
  2. Depression
  3. Upper limb fracture
  4. Wrist fracture
  5. Drug ineffective
  6. Fall
  7. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  8. Radius fracture
  9. Ulna fracture (fracture inside bone)
  10. Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 30.00%
  2. Headache (pain in head): 17 people, 28.33%
  3. Depression: 14 people, 23.33%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 23.33%
  5. High Blood Pressure: 13 people, 21.67%
  6. Stress And Anxiety: 12 people, 20.00%
  7. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 20.00%
  8. High Blood Cholesterol: 11 people, 18.33%
  9. Gastrointestinal Motility Disorder (abnormal intestinal contractions): 9 people, 15.00%
  10. Constipation: 8 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Reclast and Maxalt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Reclast:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Maxalt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Reclast and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Maxalt and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid and rizatriptan benzoate (the active ingredients of Reclast and Maxalt, respectively), and Reclast and Maxalt (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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