Reclast and Metoclopramide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reclast (zoledronic acid) and Metoclopramide (metoclopramide hydrochloride). Common drug interactions include hypersomnia among females and capillary leak syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Reclast and Metoclopramide. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

38 people who take Reclast and Metoclopramide together, and have interactions are studied.

Reclast and Metoclopramide drug interactions.

What are the common drug interactions of Reclast and Metoclopramide, by gender? *:

female:

Hypersomnia (excessive daytime sleepiness (eds))
Hypertension (high blood pressure)
Irritable bowel syndrome
Joint crepitation
Mean cell volume increased (more than normal average red blood cell volume)
Muscle spasms (muscle contraction)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Arthralgia (joint pain)

male:

Capillary leak syndrome (capillary leaks plasma)
Arthralgia (joint pain)
Peripheral swelling
Renal failure (kidney dysfunction)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Weight increased
Dizziness
Vestibular neuronitis (inflammation of the vestibular nerve)
Bone density decreased
Drug ineffective

What are the common drug interactions of Reclast and Metoclopramide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Bone loss
Comminuted fracture (bone has broken into several pieces)
Femur fracture
Gastrointestinal tract irritation
Iatrogenic injury (iatrogenic injury is a form of medical error)
Pain in extremity
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

40-49:

Arthralgia (joint pain)
Bone loss
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Comminuted fracture (bone has broken into several pieces)
Fall
Femur fracture
Gastrointestinal tract irritation
Iatrogenic injury (iatrogenic injury is a form of medical error)
Pain in extremity
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)

50-59:

Pain
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Viral upper respiratory tract infection
Abdominal distension
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Dehydration (dryness resulting from the removal of water)

60+:

Capillary leak syndrome (capillary leaks plasma)
Dizziness
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pain in extremity
Urinary tract infection
Abdominal pain upper
Activities of daily living impaired
Blood copper decreased
Chest pain
Decreased appetite

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 23.68%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 10.53%
Indigestion: 4 people, 10.53%
Sleep Disorder: 3 people, 7.89%
Tumor Lysis Syndrome: 2 people, 5.26%
Fever: 2 people, 5.26%
Allergic Rhinitis: 2 people, 5.26%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 5.26%
Blood Pressure Abnormal: 2 people, 5.26%
Cardiac Disorder: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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