Reglan and Lonox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reglan (metoclopramide hydrochloride) and Lonox (atropine sulfate; diphenoxylate hydrochloride). Common drug interactions include stomatitis among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Reglan and Lonox. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Lonox?

Lonox has active ingredients of atropine sulfate; diphenoxylate hydrochloride. eHealthMe is studying from 376 Lonox users. Check the latest studies of Lonox.

On Jul, 31, 2026

12 people who take Reglan and Lonox together, and have interactions are studied.

What are the common drug interactions of Reglan and Lonox, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Febrile neutropenia (fever with reduced white blood cells)
Infection
Abdominal pain
Ammonia increased
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cardiac failure
Cardiac failure congestive
Diarrhoea
Hepatitis (inflammation of the liver)

male:

Vomiting
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Abdominal pain
Gastritis (inflammation of stomach)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Oesophageal ulcer (ulcer of oesophagus)
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Blood creatinine increased
Cytomegalovirus infection
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Reglan and Lonox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

n/a

40-49:

Klebsiella infection
Oesophageal candidiasis (fungal infection of oesophagus)
Restlessness (not able to rest)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Abdominal pain
Gastritis (inflammation of stomach)
Herpes simplex (herpes simplex is a common viral infection)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)

50-59:

n/a

60+:

Infection
Cardiac failure
Cardiac failure congestive
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)
Vomiting

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 3 people, 25.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Pain: 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Migraine (headache): 2 people, 16.67%
Diarrhea: 2 people, 16.67%
Sleep Disorder: 1 person, 8.33%
Gastritis (inflammation of stomach): 1 person, 8.33%
Anaemia Of Malignant Disease: 1 person, 8.33%
Birth Control: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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