Reglan and Relistor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Reglan (metoclopramide hydrochloride) and Relistor (methylnaltrexone bromide). Common drug interactions include upper respiratory tract infection among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Reglan and Relistor. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Relistor?

Relistor has active ingredients of methylnaltrexone bromide. eHealthMe is studying from 1,659 Relistor users. Check the latest studies of Relistor.

On Jul, 08, 2026

48 people who take Reglan and Relistor together, and have interactions are studied.

What are the common drug interactions of Reglan and Relistor, by gender? *:

female:

Upper respiratory tract infection
Respiratory distress (difficulty in breathing)
Spinal cord compression
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Anxiety
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Contusion (a type of hematoma of tissue in which capillaries)
Lacrimation increased
Blood glucose increased
Hypercoagulation (increased tendency for clotting of the blood)

male:

Constipation
Weight decreased
Dry skin
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Gait disturbance
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

What are the common drug interactions of Reglan and Relistor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective

20-29:

n/a

30-39:

Cellulitis (infection under the skin)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Staphylococcal abscess (pus formation due to staphylococcal bacteria)
Abdominal distension
Confusional state
Diarrhoea
Enteritis (inflammation of the small intestine)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Leukopenia (less number of white blood cells in blood)

40-49:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Renal failure (kidney dysfunction)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Ventricular extrasystoles (premature cardiac contraction)
Constipation
Death
Diarrhoea
Dizziness

50-59:

Spinal osteoarthritis (joint cartilage loss in spine)
Spinal pain (pain in spine)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Stomatitis (inflammation of mucous membrane of mouth)
Synovial cyst (cyst of joint filled with synovial fluid)
Temperature intolerance (inability to go in temperature)
Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection
Varicella
Vomiting

60+:

Insomnia (sleeplessness)
Decreased appetite
Dry skin
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Gait disturbance
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 22.92%
Breast Cancer: 10 people, 20.83%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 18.75%
Constipation: 8 people, 16.67%
High Blood Cholesterol: 7 people, 14.58%
Pain: 6 people, 12.50%
Drowsiness: 4 people, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 6.25%
Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 3 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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