Relafen and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Relafen (nabumetone) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include speech disorder among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Relafen and Hydroxyzine. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,069 Hydroxyzine users. Check the latest studies of Hydroxyzine.

On Jul, 25, 2026

41 people who take Relafen and Hydroxyzine together, and have interactions are studied.

Relafen and Hydroxyzine drug interactions.

What are the common drug interactions of Relafen and Hydroxyzine, by gender? *:

female:

Speech disorder
Lethargy (tiredness)
Oral candidiasis (fungal infection of mouth)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Coma (state of unconsciousness lasting more than six hours)
Compression fracture (fracture due to pressure caused by injury)
Death
Neoplasm malignant (cancer tumour)
Renal cyst (kidney cyst)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

male:

Alanine aminotransferase increased
Acute myocardial infarction (acute heart attack)
Drug hypersensitivity
Emotional distress
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Hyperphagia (an abnormal appetite for food)
Injury
Microcytosis (a condition in which red blood cells are unusually small)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

What are the common drug interactions of Relafen and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug hypersensitivity
Fatigue (feeling of tiredness)
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Vomiting

30-39:

n/a

40-49:

Hyperhidrosis (abnormally increased sweating)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Papillary thyroid cancer
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Flushing (the warm, red condition of human skin)

50-59:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Back injury
Chronic kidney disease
Hospitalisation
Renal failure (kidney dysfunction)
Urate nephropathy (disease or abnormality of the kidney)
Weight decreased

60+:

Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dysgeusia (disorder of the sense of taste)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash
Actinomycosis (infection that causes sores, or abscesses)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Back pain
Bone pain
Deformity (disfigurement)
Dental caries

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 36.59%
Metastases To Bone (cancer spreads to bone): 14 people, 34.15%
Breast Cancer: 13 people, 31.71%
Bone Pain: 13 people, 31.71%
Breast Cancer Metastatic: 6 people, 14.63%
Itching: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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