Remeron and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Remeron (mirtazapine) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include polyneuropathy among females and mental status changes among males.

The phase IV clinical study analyzes what interactions people have when they take Remeron and Hydrocodone. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Remeron?

Remeron has active ingredients of mirtazapine. It is often used in depression. eHealthMe is studying from 26,474 Remeron users. Check the latest studies of Remeron.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 07, 2026

41 people who take Remeron and Hydrocodone together, and have interactions are studied.

Remeron and Hydrocodone drug interactions.

What are the common drug interactions of Remeron and Hydrocodone, by gender? *:

female:

Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Sinusitis (inflammation of sinus)
Staphylococcal infection (an infection with staphylococcus bacteria)
Swollen tongue (swelling of tongue)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Tendon rupture (tear of tendon)
Tendonitis (a condition that causes pain and swelling of tendons)
Thirst

male:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Somnolence (a state of near-sleep, a strong desire for sleep)
Pathological gambling
Pyrexia (fever)
Suicidal ideation
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Asthenia (weakness)
Back pain
Bone pain
Brain cancer metastatic

What are the common drug interactions of Remeron and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Myalgia (muscle pain)
Arthralgia (joint pain)
Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Connective tissue disorder (any disease that has the connective tissues of the body)
Fatigue (feeling of tiredness)
Joint crepitation
Pain in extremity
Vasculitis (inflammation of a blood vessel or blood vessels)

50-59:

Cough
Difficulty in walking
Disease progression
Drug dependence
Drug ineffective
Drug resistance (reduction in effectiveness of a drug)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysstasia (difficulty in standing)
Dysuria (painful or difficult urination)
Erectile dysfunction

60+:

Pain in extremity
Arthralgia (joint pain)
Blood pressure increased
Chest pain
Chills (felling of cold)
Death
Dehydration (dryness resulting from the removal of water)
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Pain: 12 people, 29.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 17.07%
Hepatitis C: 6 people, 14.63%
Insomnia (sleeplessness): 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Stress And Anxiety: 3 people, 7.32%
Nausea (feeling of having an urge to vomit): 3 people, 7.32%
Back Pain: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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