Requip and Neoral drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Neoral (cyclosporine). Common drug interactions include chest pain among females and blood creatinine increased among males.
The phase IV clinical study analyzes what interactions people have when they take Requip and Neoral. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.
What is Requip?
Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.
What is Neoral?
Neoral has active ingredients of cyclosporine. It is often used in psoriasis. eHealthMe is studying from 26,084 Neoral users. Check the latest studies of Neoral.
13 people who take Requip and Neoral together, and have interactions are studied.

What are the common drug interactions of Requip and Neoral, by gender? *:
female:
- Chest pain
- Fungal infection
- Gait disturbance
- Immune system disorder
- Scar
- Dyspepsia (indigestion)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Mastoiditis (infection of mastoid bone)
- Oedema peripheral (superficial swelling)
- Performance status decreased
male:
- Blood creatinine increased
- Abdominal pain
- Burning sensation
- Chest discomfort
- Chest pain
- Coma (state of unconsciousness lasting more than six hours)
- Cough
- Diarrhoea
- Disease recurrence
- Dizziness
What are the common drug interactions of Requip and Neoral, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Chest pain
- Dyspepsia (indigestion)
- Abdominal pain
- Abscess (pus)
- Angioedema (rapid swelling of the dermis)
- Arthralgia (joint pain)
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Blood pressure fluctuation
- Burning sensation
- Chest discomfort
50-59:
n/a
60+:
- Blood creatinine increased
- Fungal infection
- Diarrhoea
- Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
- Oedema peripheral (superficial swelling)
- Overdose
- Performance status decreased
- Pneumonia
- Renal failure (kidney dysfunction)
- Skin ulcer
What are the existing conditions these people have? *
- High Blood Cholesterol: 4 people, 30.77%
- Neuropathy Peripheral (surface nerve damage): 4 people, 30.77%
- Vision Blurred: 4 people, 30.77%
- Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 3 people, 23.08%
- High Blood Pressure: 3 people, 23.08%
- Fungal Infection: 3 people, 23.08%
- Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 15.38%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 15.38%
- Stress And Anxiety: 2 people, 15.38%
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 15.38%
* Approximation only. Some reports may have incomplete information.
Do you take Requip and Neoral?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Requip and Neoral:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Requip:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Neoral:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Requip and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Neoral and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on ropinirole hydrochloride and cyclosporine (the active ingredients of Requip and Neoral, respectively), and Requip and Neoral (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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