Requip and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Requip (ropinirole hydrochloride) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include paraesthesia among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Requip and Zosyn. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 11, 2026

28 people who take Requip and Zosyn together, and have interactions are studied.

What are the common drug interactions of Requip and Zosyn, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Patellofemoral pain syndrome (pain in the front of the knee)
Polydipsia (excessive thirst)
Polyuria (production of too much dilute urine)
Psychomotor skills impaired
Temperature intolerance (inability to go in temperature)
Thyroid neoplasm (tumour of thyroid)
Abdominal pain
Abdominal pain upper
Depression

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Dyspnoea (difficult or laboured respiration)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac arrest
Cardiac failure
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Requip and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Brain compression
Cerebellar infarction (impaired blood circulation to cerebellum)
Injury
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Emotional distress
General physical health deterioration (weak health status)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Abortion spontaneous (naturally occurring miscarriage)

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arthralgia (joint pain)
Balance disorder
Bladder spasm
Breast abscess
Breast cellulitis (spreading, acute inflammation of beast skin)
Breast tenderness
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

40-49:

Anxiety
Constipation
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Abdominal pain
Abdominal pain upper
Back pain
Balance disorder

50-59:

Abscess limb (limb infection)
Anal abscess
Ascites (accumulation of fluid in the abdominal cavity)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Cellulitis (infection under the skin)
Genital abscess (build up of pus in genital)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Metastases to adrenals (cancer spreads to adrenal gland of kidney)
Metastases to lymph nodes (cancer spreads to lymph node)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)

60+:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Rash
Urinary tract infection
Abdominal discomfort
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Anaemia (lack of blood)

What are the existing conditions these people have? *

Pain: 9 people, 32.14%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 17.86%
Bacteraemia (presence of bacteria in the blood): 3 people, 10.71%
Type 2 Diabetes: 2 people, 7.14%
Stress And Anxiety: 2 people, 7.14%
Staphylococcal Sepsis (blood infection by an infection with staphylococcus bacteria): 2 people, 7.14%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 7.14%
Nausea And Vomiting: 2 people, 7.14%
Nausea (feeling of having an urge to vomit): 2 people, 7.14%
Hodgkin's Lymphoma (cancer originating from white blood cells): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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