Restasis and Amerge drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Restasis (cyclosporine) and Amerge (naratriptan hydrochloride). Common drug interactions include haemorrhage among females and abdominal pain among males.
The phase IV clinical study analyzes what interactions people have when they take Restasis and Amerge. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
What is Amerge?
Amerge has active ingredients of naratriptan hydrochloride. It is often used in migraine. eHealthMe is studying from 1,470 Amerge users. Check the latest studies of Amerge.
47 people who take Restasis and Amerge together, and have interactions are studied.

What are the common drug interactions of Restasis and Amerge, by gender? *:
female:
- Haemorrhage (bleeding)
- Abdominal discomfort
- Malaise (a feeling of general discomfort or uneasiness)
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Nausea (feeling of having an urge to vomit)
- Pain
- Viral infection
- Hospitalisation
- Headache (pain in head)
- Nephrolithiasis (calculi in the kidneys)
male:
- Abdominal pain
- Clostridial infection (infectious conditions by clostridium bacteria)
- Diarrhoea
- Infusion site reaction
- Lung infection
- Nausea (feeling of having an urge to vomit)
- Vomiting
- Oedema peripheral (superficial swelling)
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
What are the common drug interactions of Restasis and Amerge, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
40-49:
- Cystitis (inflammation of the wall of the bladder)
- Hospitalisation
- Memory impairment
- Spinal fusion surgery
- Urinary tract infection
- Abdominal discomfort
- Asthma
- Bile output increased
- Diplopia (double vision)
- Dysgeusia (disorder of the sense of taste)
50-59:
- Haemorrhage (bleeding)
- Malaise (a feeling of general discomfort or uneasiness)
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Physical abuse
- Viral infection
- Weight decreased
- Herpes zoster
- Alopecia (absence of hair from areas of the body)
- Drug ineffective
- Fatigue (feeling of tiredness)
60+:
- Nausea (feeling of having an urge to vomit)
- Abdominal pain
- Infusion related reaction
- Oedema peripheral (superficial swelling)
- Pain
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
- Pyrexia (fever)
- Clostridial infection (infectious conditions by clostridium bacteria)
- Diarrhoea
- Infusion site reaction
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 31 people, 65.96%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 25.53%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 12.77%
* Approximation only. Some reports may have incomplete information.
Do you take Restasis and Amerge?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Restasis and Amerge:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Amerge:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Amerge and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on cyclosporine and naratriptan hydrochloride (the active ingredients of Restasis and Amerge, respectively), and Restasis and Amerge (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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