Restasis and Mesalamine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Restasis (cyclosporine) and Mesalamine (mesalamine). Common drug interactions include concussion among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Restasis and Mesalamine. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

What is Mesalamine?

Mesalamine has active ingredients of mesalamine. It is often used in ulcerative colitis. eHealthMe is studying from 28,053 Mesalamine users. Check the latest studies of Mesalamine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

61 people who take Restasis and Mesalamine together, and have interactions are studied.

Restasis and Mesalamine drug interactions.

What are the common drug interactions of Restasis and Mesalamine, by gender? *:

female:

Concussion (short loss of normal brain function in response to a head injury)
Connective tissue disorder (any disease that has the connective tissues of the body)
Cough
Death
Disease progression
Drug effect delayed
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Ear infection
Emotional disorder

male:

Decreased appetite
Fatigue (feeling of tiredness)
Drug hypersensitivity
Emotional distress
Haptoglobin increased
Iron deficiency anaemia
Ligament rupture (tear in ligament)
Lower limb fracture
Nephrolithiasis (calculi in the kidneys)
Osteopenia (a condition where bone mineral density is lower than normal)

What are the common drug interactions of Restasis and Mesalamine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone loss
Chronic kidney disease
Emotional distress
Ligament rupture (tear in ligament)
Lower limb fracture
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Nephrolithiasis (calculi in the kidneys)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

40-49:

Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Chronic kidney disease
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Renal failure (kidney dysfunction)
Vomiting

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ataxia (loss of full control of bodily movements)
Balance disorder
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Dysarthria (speech disorder)
Gait disturbance
Muscular weakness (muscle weakness)
Neuropathy peripheral (surface nerve damage)
Spasmodic dysphonia (a voice disorder characterized by involuntary movements or spasms of one or more muscles of the larynx)

60+:

Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Iron deficiency anaemia
Metastatic renal cell carcinoma (spreadable kidney cell tumour)
Reticulocyte count decreased
Serum ferritin increased
Vomiting
Abdominal pain lower
Anaphylactic reaction (serious allergic reaction)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 37.70%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 23 people, 37.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 19.67%
Pain: 7 people, 11.48%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 11.48%
Hypersensitivity: 7 people, 11.48%
Thyroid Diseases: 6 people, 9.84%
Nausea (feeling of having an urge to vomit): 6 people, 9.84%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 9.84%
Insomnia (sleeplessness): 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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