Restasis and Onglyza drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Restasis (cyclosporine) and Onglyza (saxagliptin hydrochloride). Common drug interactions include fall among females and aggression among males.
The phase IV clinical study analyzes what interactions people have when they take Restasis and Onglyza. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
What is Onglyza?
Onglyza has active ingredients of saxagliptin hydrochloride. It is often used in diabetes. eHealthMe is studying from 8,638 Onglyza users. Check the latest studies of Onglyza.
24 people who take Restasis and Onglyza together, and have interactions are studied.

What are the common drug interactions of Restasis and Onglyza, by gender? *:
female:
- Fall
- Asthma
- Chronic kidney disease
- Anaemia (lack of blood)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Hallucination, auditory (perceiving sounds without auditory stimulus)
- Joint injury
- Post-traumatic stress disorder
- Renal injury (kidney injury)
- Sedation
male:
- Aggression
- Lacunar infarction (a type of stroke)
- Death
- Disturbance in attention
- Dyspepsia (indigestion)
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Heart rate increased
- Lip oedema (swelling of lip)
- Pancreatic carcinoma (pancreatic cancer)
What are the common drug interactions of Restasis and Onglyza, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Fall
- Chronic kidney disease
- Hallucination, auditory (perceiving sounds without auditory stimulus)
- Joint injury
- Renal injury (kidney injury)
- Sedation
- Somnambulism (sleep walking)
- Suicide attempt
- Tachyphrenia (abnormally rapid mental activity)
- Aggression
60+:
- Abdominal pain upper
- Anxiety
- Dizziness
- Dyspepsia (indigestion)
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Heart rate increased
- Injection site haematoma (localized swelling filled with blood at injection site)
- Injection site haemorrhage (bleeding from injection site)
- Lip oedema (swelling of lip)
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 33.33%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 33.33%
- Stress And Anxiety: 5 people, 20.83%
- Multiple Allergies (allergy to multiple agents): 5 people, 20.83%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
- Depression: 3 people, 12.50%
- Insomnia (sleeplessness): 3 people, 12.50%
- Tachyphrenia (abnormally rapid mental activity): 3 people, 12.50%
- High Blood Cholesterol: 3 people, 12.50%
- Hallucination, Auditory (perceiving sounds without auditory stimulus): 3 people, 12.50%
* Approximation only. Some reports may have incomplete information.
Do you take Restasis and Onglyza?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Restasis and Onglyza:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Onglyza:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Onglyza and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on cyclosporine and saxagliptin hydrochloride (the active ingredients of Restasis and Onglyza, respectively), and Restasis and Onglyza (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Drug interactions of Flovent Hfa and Benzaclin - 19 seconds ago
- Pain In Jaw and Appetite Decreased - 20 seconds ago
- Pain In Jaw and Appetite - Decreased - 21 seconds ago
- Drug interactions of Plaquenil and Diprivan - 25 seconds ago
- Could Mycelex cause Joint Pain? - 37 seconds ago
- Could Delsym cause Throat Tightness? - 38 seconds ago
- Could Delsym cause Pain? - 39 seconds ago
- Could Febuxostat cause Hiatal Hernia? - 51 seconds ago
- Could Androgel cause Urinary Incontinence? - a minute ago
- Could Opdivo cause Belching? - a minute ago