Revatio and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Revatio (sildenafil citrate) and Vytorin (ezetimibe; simvastatin). Common drug interactions include anaphylactic reaction among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Revatio and Vytorin. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Revatio?

Revatio has active ingredients of sildenafil citrate. It is often used in pulmonary hypertension. eHealthMe is studying from 44,849 Revatio users. Check the latest studies of Revatio.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

On Jul, 18, 2026

57 people who take Revatio and Vytorin together, and have interactions are studied.

What are the common drug interactions of Revatio and Vytorin, by gender? *:

female:

Anaphylactic reaction (serious allergic reaction)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Carotid artery aneurysm (a bulging or ballooning in the wall of a blood vessel)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Death
Pulmonary embolism (blockage of the main artery of the lung)

male:

Death
Anxiety
Malaise (a feeling of general discomfort or uneasiness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pulmonary embolism (blockage of the main artery of the lung)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Malignant melanoma (skin cancer rises from melancytes)
Cardiac failure congestive
Dizziness
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Revatio and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Headache (pain in head)
Hypokalaemia (low potassium)
Leukocytosis (increased white blood cells)
Nasal dryness (dry nose)
Oedema peripheral (superficial swelling)
Peripheral swelling
Respiratory failure (inadequate gas exchange by the respiratory system)
Anxiety
Malignant melanoma (skin cancer rises from melancytes)
Adverse event

60+:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cardiac failure
Conjunctivitis (pink eye)
Depression
Emotional disorder
Fall

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 41 people, 71.93%
Depression: 4 people, 7.02%
Cardiac Disorder: 4 people, 7.02%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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