Rexulti and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Provera (medroxyprogesterone acetate). Common drug interactions include osteonecrosis among females and asthma among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Provera. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

On Jul, 07, 2026

22 people who take Rexulti and Provera together, and have interactions are studied.

What are the common drug interactions of Rexulti and Provera, by gender? *:

female:

Osteonecrosis (death of bone)
Constipation
Dyspnoea (difficult or laboured respiration)
Gastric ulcer (stomach ulcer)
Tardive dyskinesia (a disorder that involves involuntary movements)
Drug ineffective
Alopecia (absence of hair from areas of the body)
Genital haemorrhage (bleeding from genital)
Muscle spasms (muscle contraction)
Nephrolithiasis (calculi in the kidneys)

male:

Asthma
Facial pain
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Productive cough
Sinusitis (inflammation of sinus)

What are the common drug interactions of Rexulti and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Genital haemorrhage (bleeding from genital)

30-39:

Osteonecrosis (death of bone)
Arthralgia (joint pain)
Drug hypersensitivity
Eye pain
Facial pain
Headache (pain in head)
Memory impairment
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

40-49:

Constipation
Dyspnoea (difficult or laboured respiration)
Gastric ulcer (stomach ulcer)
Tardive dyskinesia (a disorder that involves involuntary movements)
Asthma
Facial pain
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Sinusitis (inflammation of sinus)

50-59:

Blood glucose fluctuation
Depressed mood
Pain in extremity
Dizziness
Drug ineffective
Alopecia (absence of hair from areas of the body)
Back pain
Death
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

60+:

n/a

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 22.73%
Migraine (headache): 3 people, 13.64%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 9.09%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 9.09%
Ovarian Disorder (disease of ovary): 2 people, 9.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 9.09%
Depression: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Rexulti and Provera?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously