Riboflavin and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Riboflavin (riboflavin (vitamin b2)) and Codeine (codeine sulfate). Common drug interactions include asthma among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Riboflavin and Codeine. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Riboflavin?

Riboflavin has active ingredients of riboflavin (vitamin b2). It is often used in migraine. eHealthMe is studying from 2,869 Riboflavin users. Check the latest studies of Riboflavin.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

86 people who take Riboflavin and Codeine together, and have interactions are studied.

Riboflavin and Codeine drug interactions.

What are the common drug interactions of Riboflavin and Codeine, by gender? *:

female:

Asthma
Drug hypersensitivity
Hypotension (abnormally low blood pressure)
Influenza like illness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pruritus (severe itching of the skin)
Drug ineffective
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cerebral haemorrhage (bleeding within the brain)
Contusion (a type of hematoma of tissue in which capillaries)

male:

Anxiety
Ataxia (loss of full control of bodily movements)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Memory impairment
Micturition urgency (urgency to pass the urine)
Monoparesis (one limb is very weak, but not completely paralyzed)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the common drug interactions of Riboflavin and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dehydration (dryness resulting from the removal of water)
Adverse event
Pyrexia (fever)

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Ataxia (loss of full control of bodily movements)
Balance disorder
Bradycardia (abnormally slow heart action)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Dizziness
Dysarthria (speech disorder)
Erectile dysfunction
Fall
Gait spastic

50-59:

Anxiety
Ataxia (loss of full control of bodily movements)
Balance disorder
Bradycardia (abnormally slow heart action)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Dizziness
Dysarthria (speech disorder)
Erectile dysfunction
Fall
Gait spastic

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cerebral haemorrhage (bleeding within the brain)
Scratch
Sinusitis (inflammation of sinus)
Skin atrophy (wasting of skin)
Upper limb fracture
Road traffic accident
Asthma
Blood pressure increased
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)

What are the existing conditions these people have? *

Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 40 people, 46.51%
Immunodeficiency Common Variable: 6 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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