Spironolactone and Prothrombin time abnormal - a phase IV clinical study of FDA data

Summary:

Prothrombin time abnormal is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Stroke.

The phase IV clinical study analyzes which people have Prothrombin time abnormal when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Prothrombin time abnormal?

Prothrombin time abnormal is found to be associated with 129 drugs and 301 conditions by eHealthMe. Check the latest studies of Prothrombin time abnormal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 25 people (0.02%) have Prothrombin time abnormal.

Could Spironolactone cause Prothrombin time abnormal?

Among these 25 people:

How long have people been on Spironolactone when they have Prothrombin time abnormal? *

What is the gender of people who have Prothrombin time abnormal when taking Spironolactone? *

female: 50 %
male: 50 %

What is the age of people who have Prothrombin time abnormal when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Prothrombin time abnormal? *

Hypotension (abnormally low blood pressure): 6 people, 24.00%
International Normalised Ratio Decreased: 5 people, 20.00%
International Normalised Ratio Increased: 5 people, 20.00%
Dizziness: 5 people, 20.00%
Nosebleed (bleeding from nose): 5 people, 20.00%
Oedema Peripheral (superficial swelling): 5 people, 20.00%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 4 people, 16.00%
International Normalised Ratio Abnormal: 4 people, 16.00%
Ascites (accumulation of fluid in the abdominal cavity): 4 people, 16.00%
Swelling: 4 people, 16.00%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 20.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 20.00%
Cardiac Amyloidosis (protein deposition in heart): 3 people, 12.00%
Cardiac Failure: 3 people, 12.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 12.00%
Osteoporosis (bones weak and more likely to break): 2 people, 8.00%
Cardiac Failure Congestive: 2 people, 8.00%
Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 2 people, 8.00%
Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 8.00%
Magnesium Deficiency (lack of magnesium): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Prothrombin time abnormal?

- Check whether Prothrombin time abnormal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Prothrombin time abnormal:

Prothrombin time abnormal (129 drugs)

Browse all the conditions that are associated with Prothrombin time abnormal:

Prothrombin time abnormal (301 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.