Rinvoq and Pentasa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rinvoq (upadacitinib) and Pentasa (mesalamine). Common drug interactions include gastrointestinal haemorrhage among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Rinvoq and Pentasa. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

On Jul, 26, 2026

17 people who take Rinvoq and Pentasa together, and have interactions are studied.

What are the common drug interactions of Rinvoq and Pentasa, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Heart rate irregular
Mastocytosis (an excessive number of apparently normal mast cells in the skin and, occasionally, in other organs)
Nasopharyngitis (inflammation of the nasopharynx)
Palpitations (feelings or sensations that your heart is pounding or racing)
Abortion induced (medically referred abortion)
Maternal exposure during pregnancy (use of substance during pregnancy)
Acne varioliformis (an inflammatory disease of the sebaceous glands and hair follicles of the skin that is marked by the eruption of pimples or pustules, especially on the face)

male:

Drug ineffective
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Pain in extremity
Pyrexia (fever)
Skin disorder (skin disease)
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)
Cytomegalovirus infection
Haemoglobin decreased
Inflammatory marker increased

What are the common drug interactions of Rinvoq and Pentasa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest discomfort
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Heart rate irregular
Herpes zoster
Irritability
Mastocytosis (an excessive number of apparently normal mast cells in the skin and, occasionally, in other organs)
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Rash
Acne varioliformis (an inflammatory disease of the sebaceous glands and hair follicles of the skin that is marked by the eruption of pimples or pustules, especially on the face)
Cardiac failure
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Hypotension (abnormally low blood pressure)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pyrexia (fever)
Uveitis (inflammation of the uvea)

50-59:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Abdominal pain upper
Frequent bowel movements
Hypotension (abnormally low blood pressure)
Infection
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachypnoea (a condition of rapid breathing over 20 per minute)

60+:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Frequent bowel movements
Guttate psoriasis (a type of psoriasis that looks like small drops on the skin)
Joint effusion (presence of extra fluid in joint covering)
Psoriasis (immune-mediated disease that affects the skin)
Tendon rupture (tear of tendon)
Aortic aneurysm rupture (enlarged aortic artery rapture caused by a weakening of the artery wall)
Cytomegalovirus infection
Haemoglobin decreased

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 12 people, 70.59%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 17.65%
High Blood Pressure: 2 people, 11.76%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%
Hepatitis B Core Antibody Positive: 1 person, 5.88%
Anaemia (lack of blood): 1 person, 5.88%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.88%
Colitis (inflammation of colon): 1 person, 5.88%
Dyslipidaemia (abnormal amount of lipids): 1 person, 5.88%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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