Contrave and Crestor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride) and Crestor (rosuvastatin calcium). Common drug interactions include weight increased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Contrave and Crestor. It is created by eHealthMe based on reports of 80 people who take the same drugs from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Crestor?

Crestor has active ingredients of rosuvastatin calcium. It is often used in high blood cholesterol. eHealthMe is studying from 149,761 Crestor users. Check the latest studies of Crestor.

On Jul, 26, 2026

80 people who take Contrave and Crestor together, and have interactions are studied.

What are the common drug interactions of Contrave and Crestor, by gender? *:

female:

Weight increased
Nausea (feeling of having an urge to vomit)
Constipation
Arthropathy
Dizziness
Asthenia (weakness)
Malaise (a feeling of general discomfort or uneasiness)
Retching (strong involuntary effort to vomit)
Hot flush (sudden feelings of heat)
Migraine (headache)

male:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Erectile dysfunction
Feeling jittery
Food craving
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Therapeutic response unexpected

What are the common drug interactions of Contrave and Crestor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hot flush (sudden feelings of heat)
Nausea (feeling of having an urge to vomit)
Parosmia (distortion of the sense of smell, as in smelling odours that are not present)
Anxiety
Hallucination, auditory (perceiving sounds without auditory stimulus)
Palpitations (feelings or sensations that your heart is pounding or racing)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypertension (high blood pressure)
Pancreatitis (inflammation of pancreas)

50-59:

Nausea (feeling of having an urge to vomit)
Dehydration (dryness resulting from the removal of water)
Food craving
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Vomiting
Abdominal pain
Chest discomfort
Constipation
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dizziness

60+:

Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Headache (pain in head)
Cystitis (inflammation of the wall of the bladder)
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)
Hyperhidrosis (abnormally increased sweating)
Abdominal distension
Anxiety
Blood pressure increased

What are the existing conditions these people have? *

High Blood Pressure: 31 people, 38.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 22.50%
Diabetes: 18 people, 22.50%
Depression: 11 people, 13.75%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 12.50%
Blood Pressure Abnormal: 9 people, 11.25%
Neuralgia (pain in one or more nerves): 7 people, 8.75%
Blood Glucose Abnormal: 6 people, 7.50%
Weight Decreased: 6 people, 7.50%
Pain: 6 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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