Ritalin la and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin la (methylphenidate hydrochloride) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include chronic obstructive pulmonary disease among females and apathy among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin la and Vicodin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin la?

Ritalin la has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,563 Ritalin la users. Check the latest studies of Ritalin la.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.



On Jul, 13, 2026

21 people who take Ritalin la and Vicodin together, and have interactions are studied.

Ritalin la and Vicodin drug interactions.

What are the common drug interactions of Ritalin La and Vicodin, by gender? *:

female:

  1. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  2. Dysphagia (a condition in which swallowing is difficult or painful)
  3. Nausea (feeling of having an urge to vomit)
  4. Vomiting
  5. Gastrointestinal pain
  6. Heart rate increased
  7. Hypotension (abnormally low blood pressure)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Nasopharyngitis (inflammation of the nasopharynx)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

male:

  1. Apathy
  2. Dehydration (dryness resulting from the removal of water)
  3. Swelling
  4. Anxiety
  5. Drug abuse
  6. Drug dependence
  7. Emotional distress
  8. Learning disability (difficulty in learning)
  9. Overdose
  10. Enuresis (repeated inability to control urination)

What are the common drug interactions of Ritalin La and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anxiety
  2. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  3. Drug abuse
  4. Drug dependence
  5. Emotional distress
  6. Learning disability (difficulty in learning)
  7. Overdose
  8. Pelvic venous thrombosis (blood clot occurring inside a blood vessel and thromboses (dvts) that form in the deep veins of the legs or in the pelvic veins)
  9. Phlebitis superficial (inflammation of the walls of a vein-superficial)

30-39:

  1. Dehydration (dryness resulting from the removal of water)
  2. Enuresis (repeated inability to control urination)
  3. Food craving
  4. Influenza
  5. Loss of consciousness
  6. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  7. Weight decreased
  8. Chills (felling of cold)
  9. Initial insomnia (feeling of inadequate or poor-quality sleep)
  10. Night sweats (sweating in night)

40-49:

n/a

50-59:

n/a

60+:

  1. Abnormal dreams
  2. Arrhythmia (irregular heartbeat)
  3. Exostosis (formation of new bone on the surface of a bone)
  4. Insomnia (sleeplessness)
  5. Intervertebral disc disorder (spinal disc disorder)
  6. Intervertebral disc protrusion (spinal disc protrusion)
  7. Intervertebral disc space narrowing (spinal disc space narrowing)
  8. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  9. Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 57.14%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 33.33%
  3. Sleep Disorder: 2 people, 9.52%
  4. Drowsiness: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ritalin la and Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ritalin la:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ritalin la and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vicodin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride and acetaminophen; hydrocodone bitartrate (the active ingredients of Ritalin la and Vicodin, respectively), and Ritalin la and Vicodin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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