Simponi and Nabumetone drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Simponi (golimumab) and Nabumetone (nabumetone). Common drug interactions include fatigue among females and drug ineffective among males.
The phase IV clinical study analyzes what interactions people have when they take Simponi and Nabumetone. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.
What is Simponi?
Simponi has active ingredients of golimumab. It is often used in rheumatoid arthritis. eHealthMe is studying from 86,328 Simponi users. Check the latest studies of Simponi.
What is Nabumetone?
Nabumetone has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 9,554 Nabumetone users. Check the latest studies of Nabumetone.
38 people who take Simponi and Nabumetone together, and have interactions are studied.

What are the common drug interactions of Simponi and Nabumetone, by gender? *:
female:
- Fatigue (feeling of tiredness)
- Pain in extremity
- Photosensitivity reaction
- Back pain
- Dyspepsia (indigestion)
- Gastrointestinal disorder (functional problems of gastrointestinal tract)
- Irritable bowel syndrome
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
- Peripheral ischaemia (impaired circulation to an extremity)
male:
- Drug ineffective
- Nausea (feeling of having an urge to vomit)
- Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
- Injection site cellulitis (injection site inflammation)
- Muscle spasms (muscle contraction)
- White blood cell count increased
- Cataract (clouding of the lens inside the eye)
- Iritis (painful inflammation of the iris of the eye)
- Joint stiffness
- Joint swelling
What are the common drug interactions of Simponi and Nabumetone, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Drug ineffective
- Energy increased
- Upper respiratory tract infection
30-39:
- Blood triglycerides decreased
- Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
- White blood cell count increased
40-49:
- Arthralgia (joint pain)
- Injection site haemorrhage (bleeding from injection site)
- Infection
- Injection site reaction
50-59:
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Dry eye (lack of adequate tears)
- Dry mouth
- Fatigue (feeling of tiredness)
- Hypersomnia (excessive daytime sleepiness (eds))
- Stress
- Swelling face
- Viral upper respiratory tract infection
- Vomiting
- Contusion (a type of hematoma of tissue in which capillaries)
60+:
- Squamous cell carcinoma (a cancer of a kind of epithelial cell)
- Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
- Femur fracture
- Gastric ulcer (stomach ulcer)
- Gastritis (inflammation of stomach)
- Memory impairment
- Muscle spasms (muscle contraction)
- Osteopenia (a condition where bone mineral density is lower than normal)
- Pneumonia legionella (pneumonia caused by the bacteria legionella)
- Renal failure (kidney dysfunction)
What are the existing conditions these people have? *
- Ankylosing Spondylitis (type of arthritis affecting the spine): 14 people, 36.84%
- Stress And Anxiety: 4 people, 10.53%
- Pain In Extremity: 4 people, 10.53%
- Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 3 people, 7.89%
- Pain: 3 people, 7.89%
- Joint Pain: 3 people, 7.89%
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 7.89%
- High Blood Pressure: 3 people, 7.89%
- High Blood Cholesterol: 3 people, 7.89%
- Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.26%
* Approximation only. Some reports may have incomplete information.
Do you take Simponi and Nabumetone?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Simponi (86,328 reports)
- Nabumetone (9,554 reports)
Browse all drug interactions of Simponi and Nabumetone:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Simponi:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Nabumetone:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Simponi and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Nabumetone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Azuma N, Matsui K, Hashimoto N, Yoshikawa T, Sano H, "Successful Switch to Golimumab for Eosinophilia and Skin Symptoms Related to Multiple Biologics in a Patient with Rheumatoid Arthritis", Internal Medicine, 2017 Jun .
- Hung SC, Liao KF, Hung HC, Lin CL, Lai SW, Lin CH, "Nabumetone use and risk of acute pancreatitis in a case-control study", Pancreatology, 2016 Jun .
- Azuma N, Matsui K, Hashimoto N, Yoshikawa T, Sano H, "Successful Switch to Golimumab for Eosinophilia and Skin Symptoms Related to Multiple Biologics in a Patient with Rheumatoid Arthritis", Internal Medicine, 2017 Jun .
- Hung SC, Liao KF, Hung HC, Lin CL, Lai SW, Lin CH, "Nabumetone use and risk of acute pancreatitis in a case-control study", Pancreatology, 2016 Jun .
How the study uses the data?
The study uses data from the FDA. It is based on golimumab and nabumetone (the active ingredients of Simponi and Nabumetone, respectively), and Simponi and Nabumetone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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