Zyrtec and Orladeyo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zyrtec (cetirizine hydrochloride) and Orladeyo (berotralstat hydrochloride). Common drug interactions include hereditary angioedema among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zyrtec and Orladeyo. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

What is Orladeyo?

Orladeyo has active ingredients of berotralstat hydrochloride. eHealthMe is studying from 347 Orladeyo users. Check the latest studies of Orladeyo.

On Jul, 13, 2026

26 people who take Zyrtec and Orladeyo together, and have interactions are studied.

What are the common drug interactions of Zyrtec and Orladeyo, by gender? *:

female:

Hereditary angioedema (recurrent episodes of severe swelling)
Intervertebral disc protrusion (spinal disc protrusion)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Nasopharyngitis (inflammation of the nasopharynx)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Rash
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Dizziness

male:

Diarrhoea
Swollen tongue (swelling of tongue)
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

What are the common drug interactions of Zyrtec and Orladeyo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Nasopharyngitis (inflammation of the nasopharynx)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Rash
Dizziness

40-49:

Swollen tongue (swelling of tongue)
Abdominal pain
Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Somnolence (a state of near-sleep, a strong desire for sleep)
Swelling
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Haematochezia (passage of stools containing blood)

50-59:

n/a

60+:

Abdominal discomfort
Asthenia (weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Rash
Skin burning sensation
Diarrhoea
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Headache (pain in head)

What are the existing conditions these people have? *

Hereditary Angioedema (recurrent episodes of severe swelling): 14 people, 53.85%
Immune System Disorder: 10 people, 38.46%
Immunodeficiency Common Variable: 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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