Ritalin and Clarinex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ritalin (methylphenidate hydrochloride) and Clarinex (desloratadine). Common drug interactions include blood sodium increased among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Ritalin and Clarinex. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

What is Clarinex?

Clarinex has active ingredients of desloratadine. It is often used in allergies. eHealthMe is studying from 6,463 Clarinex users. Check the latest studies of Clarinex.

On Aug, 09, 2026

62 people who take Ritalin and Clarinex together, and have interactions are studied.

What are the common drug interactions of Ritalin and Clarinex, by gender? *:

female:

Blood sodium increased
Burning sensation
Candidiasis (candidiasis or thrush is a fungal infection)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Chorea (abnormal involuntary movement disorder)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Compulsions (performing an act persistently and repetitively)
Concussion (short loss of normal brain function in response to a head injury)
Constipation

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Renal impairment (severely reduced kidney function)
Suicidal ideation
Decreased appetite
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Haemoglobin decreased

What are the common drug interactions of Ritalin and Clarinex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Compulsions (performing an act persistently and repetitively)
Drug ineffective
Pain in extremity
Skin warm
Swelling
Tremor (trembling or shaking movements in one or more parts of your body)
Urticaria (rash of round, red welts on the skin that itch intensely)
Weight increased

10-19:

Abdominal pain upper
Abnormal behaviour
Aggression
Chest pain
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Intentional self-injury
Irritability
Mood swings (an extreme or rapid change in mood)
Somnolence (a state of near-sleep, a strong desire for sleep)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Loss of employment
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Renal impairment (severely reduced kidney function)
Renal failure (kidney dysfunction)

30-39:

Blepharospasm (any abnormal contraction or twitch of the eyelid)
Cardiac disorder
Drug toxicity
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Night sweats (sweating in night)
Scar
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal fusion surgery
Suicide attempt

40-49:

Weight decreased
Fall
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood pressure increased
Coeliac disease (simple food intolerance)
Dizziness
Drug detoxification

50-59:

Cardiomegaly (increased size of heart than normal)
Injection site pruritus (severe itching at injection site)
Injection site rash
Weight increased
Asthma
Cardiac failure
Drug ineffective
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Activities of daily living impaired
Ageusia (loss of taste functions of the tongue)

60+:

Vitamin d increased
Decreased appetite
Weight decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug ineffective
Feeling jittery
Feeling of despair
Haemoglobin decreased
Hallucination, auditory (perceiving sounds without auditory stimulus)
Impulsive behaviour

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 42 people, 67.74%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 16.13%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.45%
Drowsiness: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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